Pulmonary lymphangiomyomatosis (LAM) is a rare disease of unknown aetiology which occurs exclusively in women, usually of reproductive age. The findings on CT and high-resolution CT (HRCT) are well described and characteristic, and in a young woman they are virtually pathognomonic. A case of symptomatic, radiological and measured lung function deterioration following contrast-enhanced CT in a patient with LAM are reported here. These observations, to the authors' knowledge, have never been reported before. The authors attempt to explain these observations based on the known pathology of LAM.
BackgroundCervical cancer (CC) is one of the common malignant tumors in women, Currently, 30% of patients with intermediate to advanced squamous cervical cancer are still uncontrolled or recurrent after standard radical simultaneous radiotherapy; therefore, the search for critical genes affecting the sensitivity of radiotherapy may lead to new strategies for treatment.MethodsFirstly, differentially expressed genes (DEGs) between radiotherapy-sensitivity and radiotherapy-resistance were identified by GEO2R from the gene expression omnibus (GEO) website, and prognosis-related genes for cervical cancer were obtained from the HPA database. Subsequently, the DAVID database analyzed gene ontology (GO). Meanwhile, the protein-protein interaction network was constructed by STRING; By online analysis of DEGs, prognostic genes, and CCDB data that are associated with cervical cancer formation through the OncoLnc database, we aim to search for the key DEGs associated with CC, Finally, the key gene(s) was further validated by immunohistochemistry.Result298 differentially expressed genes, 712 genes associated with prognosis, and 509 genes related to cervical cancer formation were found. The results of gene function analysis showed that DEGs were mainly significant in functional pathways such as variable shear and energy metabolism. By further verification, two genes, ASPH and NKAPP1 were identified through validation as genes that affect both sensitivities to radiotherapy and survival finally. Then, immunohistochemical results showed that the ASPH gene was highly expressed in the radiotherapy-resistant group and had lower Overall survival (OS) and Progression-free survival (PFS).ConclusionThis study aims to better understand the characteristics of cervical cancer radiation therapy resistance-related genes through bioinformatics and provide further research ideas for finding new mechanisms and potential therapeutic targets related to cervical cancer radiation therapy.
Background: Cervical cancer is one of the common malignant tumors in women, among which squamous cell carcinoma of the cervix accounts for more than 90%. Currently, 30% of patients with intermediate to advanced squamous cervical cancer are still uncontrolled or recurrent after standard radical simultaneous radiotherapy; therefore, the search for key genes affecting the sensitivity of radiotherapy may lead to new strategies for treatment.Methods: Differentially expressed genes were identified by GEO2R from the gene expression omnibus (GEO) website, prognosis-related genes for cervical cancer were obtained from other databases, then gene ontology (GO) was analyzed by DAVID. Meanwhile, protein-protein interaction network was constructed by STRING, By Online analysis of differentially expressed genes, prognostic genes, and CCDB(cervical cancer gene database website: http://crdd.osdd.net/raghava/ccdb/index.php) through the OncoLnc database, we aim to search for differentially expressed genes associated with prognosis validation by immunohistochemistry.Result: 298 differentially expressed genes, 724 genes associated with prognosis were found. Eventually, 2 genes, ASPH and NKAPP1, were identified through validation as genes that affect both sensitivities to radiotherapy and survival. Then, immunohistochemical results showed that the ASPH gene was indeed highly expressed in the radiotherapy-resistant group and had lower OS and PFS.Conclusion: This study aims to better understand the characteristics of cervical cancer radiation therapy resistance-related genes through bioinformatics, and provide further research ideas for finding new mechanisms and potential therapeutic targets related to cervical cancer radiation therapy.
Dosimetric comparison between the use of insertion needles and Fletcher applicator in brachytherapy for cervical cancer INTRODUCTIONCervical cancer is the common cancer diagnosed in women worldwide, and cervical squamous cell carcinoma accounts for a larger proportion. Adequate radiotherapy dose is the primary factor for improving local control rates among patients with cervical squamous cell carcinoma (1) . Two types of radiotherapy are used for the treatment of cervical cancer: external beam radiation therapy and brachytherapy (also known as afterload). Brachytherapy is indispensable as a radical radiotherapy for cervical cancer. It possesses a physical dosimetric advantage, that is, the inverse square law, which enables tumors to receive relatively high doses of radiation while reducing the amount of radiation received by surrounding normal tissues. A dose of 80-100 Gy may be used for primary cervical lesions
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