Smokeless tobacco comes in two different forms, which are 'tobacco snuff' and 'chewing tobacco'. Tobacco snuff is the powdered form blended with potash as the main additive in Nigeria. This eight-week study was designed to investigate the effect of tobacco snuff consumption on organ weight. A total of (42) Adult Wistar rats weighing 150-300g were involved. They were divided into four groups; group A serving as control, while groups B, C and D served as the test groups. The test groups were further divided into four groups (B1, C1, D1; B2, C2, D2; B3, C3, D3; and B4, C4, D4) representing four experimental phases/duration of 2, 4, 6 and 8 weeks respectively. The rats were fed with varying doses of tobacco snuff and at the end of every 2 weeks; three randomly selected rats were prepared for organ harvest followed by organ weight measurement. The results showed statistically significant organ weight changes throughout the study. Heart, liver, lungs, spleen, small intestine, right and left kidney and right and left testis all presented organ weight loss when test groups were compared with the control. Brian showed both increase and decrease Original Research Article
This study was designed to investigate the effect of tobacco snuff consumption on total protein, albumin, globulin and fasting blood sugar level. Adult Wistar rats (12) weighing 150-300g were involved. They were divided into four groups; group A serving as control, while groups B, C and D served as the test groups. The rats were fed with varying doses of tobacco dust mixed with potash (tobacco snuff). At the end of the experiment, the animals were sacrificed and blood sample collected into lithium heparin container. Total protein (24.34 ± 4.10 g/dl), albumin (13.80 ± 4.66 g/dl), and fasting blood sugar were assayed and the results obtained showed statistically significant changes. However, fasting blood sugar (117.33 ± 38.50mg/dl) showed decrease that was not statistically significant in all the groups throughout the experiment. The results of this study suggest that tobacco snuff is toxic to the synthetic capacity of the liver and the observed changes were dose dependent.
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