Tobacco Snuff Induced Organ Weight Changes

Ugbor, CI; Okonkwo, LO; Nwaopara, AO; Duhu, N. J.; Odo, E. I.

doi:10.9734/jammr/2018/29692

Cited by 3 publications

(6 citation statements)

References 27 publications

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“…Another study conducted in 2021 showed the similar results of increased creatinine and urea level as current study after treatment with ST. The results of current research work accorded with Ugbor et al, who noted that consumption of ST caused the reduction in weight of right and left kidney [17].…”

Section: Discussionsupporting

confidence: 90%

Effects of Smokeless Tobacco on the Histology and Functioning of Proximal Convoluted Tubules of the Kidneys of Female Albino Rats

Singha¹,

Qazi²,

Isaac³

2021

JPRI

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Aims: The consumption of oral form of smokeless tobacco has increased rapidly. Its use is associated with increased risk of chronic diseases like diabetes, myocardial infarction, liver disorders, cerebrovascular accidents and many other health issues. Use of tobacco in any form either smoked or chewed form leads to the absorption of nicotine which spontaneously moves into the bloodstream where it is circulated throughout the body system. Hence through this study an effort is being made to evaluate the effects produced by the locally available brand of smokeless tobacco on the histology and functioning of proximal convoluted tubules of the kidneys of the female Swiss albino rats. Place and Duration of Study: The study was conducted in Sindh Agricultural University, Tandojam and further lab work was carried out in Isra University Hyderabad. Methodology: 30 adult female Swiss albino rats were randomly selected. They were divided into three groups (n=10). Group A were taken as control. Group B&C comprised of rats which were given 5 %& 10% of smokeless tobacco respectively along with their chow diet. The feed and water were given ad libitum. Animals were sacrificed on 31st day and their kidneys were removed and weighed. The specimens were processed routinely for examination under light microscope. The sections were stained using H & E stains and examined under light microscope. Blood samples for analysis of creatinine and urea were collected. Results: A significant decrease in the weight of the kidneys, an increase in the levels of creatinine and urea were observed (P value = 0.001). Kidneys of both B & C groups showed edema, congestion and presence of cast cells when compared with the kidneys of the control group. Conclusion: From these observations, it can be inferred that the exposure of female Swiss albino rats to the smokeless form of Tobacco is associated with structural and functional damage of the kidneys.

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Section: Discussionsupporting

confidence: 90%

Effects of Smokeless Tobacco on the Histology and Functioning of Proximal Convoluted Tubules of the Kidneys of Female Albino Rats

Singha¹,

Qazi²,

Isaac³

2021

JPRI

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“…The histological features of the liver tissues as observed under the microscope for the control group (A) and test groups (B, C and D) were represented by the micrographs in Fig. (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The results showed that the liver section from the control group (A) presented normal histological features (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The concentrations of tobacco used in this study were deduced from the work of Bagchi et al 22 while, that of potash was deduced from Ugbor et al 10 .…”

Section: Study Durationmentioning

confidence: 99%

“…Moreover, the two different forms of smokeless tobacco are tobacco snuff and chewing tobacco 4 , although the most popular brand in Nigeria is tobacco snuff. Tobacco snuff is the powdered form with potash as the main additive [5][6][7] and due to the form, it is seen as the replacement for nicotine as cigarette contains known hazardous elements 8 and many believed it is not dangerous. However, addiction to nicotine and leukoplakia has been induced by smokeless tobacco 9 .…”

Section: Introductionmentioning

confidence: 99%

“…However, addiction to nicotine and leukoplakia has been induced by smokeless tobacco 9 . In addition, Nigerian tobacco snuff has been proven to induce priapism with consequential necrosis 10 . Also, local tobacco snuff has proven to be harmful to the lungs, kidneys and liver as reported 6,7,[11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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Tobacco Snuff-Induced Hepatic Alterations

Ugbor¹,

Okoeguale²,

Nwobodo³

et al. 2023

J. of Pharmacology and Toxicology

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Background and Objective: Tobacco snuff in Nigeria is the blended dried tobacco left with potash. This substance has been proven to cause systemic distortions and its consumption is unhealthy, thus tobacco snuff-induced hepatic alterations were investigated. Materials and Methods: In this study (8 weeks), liver histological changes were investigated after tobacco snuff ingestion. Forty-two experimental animals (Wister rats) were involved and they were divided into groups A (control), group B (test group 1), C (test group 2) and D (test group 3). The test groups were further divided into four groups receiving 2.4, 4.8 and 7.2 g graded doses of tobacco snuff for the experimental duration of 8 weeks. The experimental duration was phased into 2 weeks and at the end of each 2 weeks, liver organs were harvested for analysis. Results: Hepatic tissue damage was observed through examination of the stained paraffin-embedded sections. Edematous changes with parenchymal erosion as well as cellular necrosis, vacuolations, hemorrhagic exudations, inflammatory cellular infiltration, severe cellular infiltration, cellular degeneration and distortions of parenchymal tissue architecture were observed among the experimental animals. Conclusion: The present results showed that tobacco snuff is capable of inducing severe liver damage and the observed damages were dose and duration-dependent.

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