The ligand, salicylaldehyde Girard-T hydrazonium chloride, [H 2 SalGT]Cl (1), and two complexes [Cu(HSalGT)X 2 ] · H 2 O (X = Br(2); Cl(3)) were synthesized and their crystal structures were determined by singlecrystal X-ray analysis. In the two isostructural complexes, the Cu(II) is located in a square-pyramidal environment, with the chelating ligand and one halogen atom in the basal plane and the second halogen in the apical position. The most apparent structural difference between the 1 and its complexes 2 and 3 is the orientation of the N(CH 3 ) 3 group: in 1, it is practically coplanar to the rest of the molecule, while in 2 and 3 it is oriented to the side of the axially bonded halogen, which can be explained by the C-H. . .X intramolecular interactions. The compounds were characterized by elemental analysis, molar conductivity, magnetic susceptibility and electronic absorption spectra.

Five pentacoordinate copper(II) complexes with 2‐acetylpyridine or di(2‐pyridyl) ketone 1‐adamantoyl hydrazone ligands (Adpy and Addpy, respectively) of the formulae [CuCl2(Adpy)] (1), [Cu2(μ‐Cl)2(Adpy‐H)2] (2), [Cu(NCS)2(Adpy)] (3), [Cu2(μ‐Cl)2(Addpy‐H)2] (4), and [Cu2(NCS)2(μ‐Addpy‐H)2] (5) were synthesized and characterized by spectral, electrochemical, and X‐ray structural analysis. Flow cytometry and morphological analysis confirmed that the copper(II) complexes 2 and 5 induced accumulation of a sub‐G1 phase population, and fluorescence microscopy indicated the presence of large cells in apoptosis. The interaction of the copper(II) complexes with calf thymus DNA (CT‐DNA) was monitored by changes in their UV/Vis spectra. The observed intrinsic binding constants for 2 and 5 (Kb = 1.77 × 106 and 3.58 × 106 M–1, respectively) together with ethidium displacement fluorescence experiments indicate intercalative binding. Complexes 2 and 5 showed nuclease activity against pUC19 plasmid DNA.

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There is a complex interplay between the structural and other physicochemical properties of new compounds and the molecules in living organisms. To understand the mechanism of the interactions at the molecular level, the correlations between the selected properties and their biological responses have to be examined. With this aim, in this paper, density functional theory (DFT) and LMP2 calculations were carried out for the 2-acetylpyridine-aminoguanidine ligand, L, and its copper(II) complexes containing different monoanionic ligands. In addition, several parameters, most frequently used for the prediction of drug-likeness of new compounds, were calculated. The influence of the compounds on the effectiveness of the reference chemotherapeutic drug cisplatin was determined in vitro, by comparison of their combination indices (CIs). The drug interactions between cisplatin and the earlier synthesized ligands L1 (bis(3-chloropyridazine-6-hydrazone)-2,6-diacetylpyridine) and L2 (bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine) and their Co(III), Ni(II), Cu(II) and Zn(II) complexes, respectively, were also measured. The ligands L, L2, and L3, as well as their complexes, showed different interactions in combination with cisplatin from strong antagonism of L to strong synergism of 4-L1 and 4-L2. The experimental results and the calculated parameters were analyzed to evaluate their correlation with the measured interactions. The thermal stability of the LÁ2HCl ligand and its four copper(II) complexes was determined and the thermal stability data were correlated to selected calculated molecular descriptors.

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This is the first review dealing with the coordination chemistry of metal complexes with Girard's reagents and their hydrazones. The short introduction points out to chemical properties and significance of these organic compounds. The next section briefly describes synthetic methods for preparing complexes with Girard's reagents, as well as modes of coordination of these ligands. The last two extensive sections review the preparation, stereochemistry and structural characteristics of metal complexes with Girard's hydrazones, including some newer non-hydrazonic derivatives of Girard's reagents, also.[Acknowledgments. Projekat Ministarstva nauke Republike Srbije, br. 172014

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In the continuation of our systematic research of pyrazole coordination compounds, complexes of Cu(II), Ni(II), Co(II) and Zn(II) with 4-nitro-3-pyrazolecarboxylic acid ligand (L) were synthesized in the reaction of warm ethanolic solutions of the ligand and CuCl 2 Á2H 2 O, Ni(CH 3 COO) 2 , CoCl 2 Á6H 2 O and Zn(CH 3 COO) 2 , mixed in the metal-to-ligand ratio of 1:2. As the compounds could not be obtained in the form suitable for single-crystal structure analysis, their bis(ligand) structures, ML 2 (M = Cu II , Ni II , Co II and Zn II ) were proposed on the basis of elemental analysis, IR spectrometry, conductometric and TG-MS measurements. The low conductivity of the compounds additionally supports the deprotonation of the ligand and the formation of neutral complexes. The solvent content was calculated using the thermogravimetric (TG) data. According to TG data, the copper(II) compound crystallizes with 8 while nickel(II) complex with 4 water molecules, CuL 2 Á8H 2 O, NiL 2 Á4H 2 O. Complexes of Co(II) and Zn(II) contain 1 and 1.5 water molecules. Despite the differences in solvation properties, the high similarity in the course of the decomposition refers to the similar coordination mode of the organic ligand. The crystal and molecular structures of HLÁH 2 O and NH 4 [LHL] were determined by single-crystal X-ray structure analysis. Biological research based on determining the inhibition effect of commercial fungicide Cabrio top, ligand, and all newly synthesized complexes on Ph. viticola has been carried out using the phytosanitary method.