Transition metal complexes with Girard reagents and their hydrazones

Abstract

This is the first review dealing with the coordination chemistry of metal complexes with Girard's reagents and their hydrazones. The short introduction points out to chemical properties and significance of these organic compounds. The next section briefly describes synthetic methods for preparing complexes with Girard's reagents, as well as modes of coordination of these ligands. The last two extensive sections review the preparation, stereochemistry and structural characteristics of metal complexes with Girard's hydrazones, including some newer non-hydrazonic derivatives of Girard's reagents, also.[Acknowledgments. Projekat Ministarstva nauke Republike Srbije, br. 172014

Efficient synthesis of novel bis(dihydropyrano[2,3c]pyrazoles), bis(4H-chromenes) and bis(dihydropyrano[3,2-c]chromenes) with amide functionality

“…Pyrans and their fused analogues especially, pyrano [2,3-c]pyrazole, chromene and pyrano [3,2-c]chromenes play a fundamental role in bioorganic chemistry due to their diverse biological applications including anticancer, antiviral and anti-inflammatory activities. [19][20][21][22] Furthermore, the presence of more than one active moiety in the molecule is believed to alter positively the activity for the intended application. In the last decade, we reported extensively on the Michael addition reaction [23][24][25][26] as well as the chemistry of bis-(heterocycles) whose heterocyclic moieties were linked via different aliphatic and aromatic spacers.…”

Molecular Structures and Spin‐States of Pseudohalide Metal Complexes with Hydrazones of Girard's T Reagent

“…The Girard T reagent was first synthesized by A. Girard and G. Sandulesco in 1936, on treatment of ethyl chloroacetate with trimethylamine . Of the Girard reagents, the largest number of complexes have been synthesized with Girard T. In the reported complexes the Girard T reagent has been coordinated to metal ions through the terminal hydrazine nitrogen atom and the carbonyl oxygen atom, forming a five‐membered chelate ring . Whereas the chemistry of acylhydrazone and semicarbazone metal complexes has been intensively studied, relatively small number of metal complexes with Girard reagent hydrazones have been synthesized until now.…”

“…Whereas the chemistry of acylhydrazone and semicarbazone metal complexes has been intensively studied, relatively small number of metal complexes with Girard reagent hydrazones have been synthesized until now. In the reported complexes, the Girard reagents hydrazones behave variously as mono‐, di‐, tri‐, and pentadentate ligands . The Girard T reagent hydrazones exhibit keto–enol tautomerism and can coordinate metal ions either in non‐deprotonated positively charged form or in deprotonated formally neutral zwitterionic form.…”

“…In 2012 Leovac et al provided a detailed review about metal complexes with Girard reagents and their hydrazones . That review also covers some pseudohalide metal complexes with Girard T reagent hydrazones reported up until 2012 , .…”

Synthesis and Antimicrobial Study of Novel 1‐Benzylated Water‐Soluble Isatin‐3‐hydrazones

“…Their high reactivity towards carbonyl compounds has been successfully used in mass‐spectrometric determination of steroids in biological samples. [ ][ ] In addition, it is known that a number of acylhydrazones on the base of Girard's reagents and their metal complexes exhibit a wide range of biological activity …”