Graphical abstract

Precise control over the monomeric sequence on natural sequence-defined polymers (SDPs) leads to their structural diversity and functions. However, absolute control over the monomeric sequence on a synthetic polymer remains a challenging process. Herein, we describe a supportfree, protection−deprotection-free, cost-effective, and fast iterative strategy for multigram production of a new class of SDP with a unique functional group, dithiocarbamate, a potential group for material and biomedical applications. The strategy is based on a unique monomer, named as amine-hydroxyl monomer, and a three-component reaction between the monomer, CS 2 , and terminal chloro group of the growing chain. The fast strategy allows us to synthesize a 5mer sequence-defined oligomer in 6 h. For a proof of concept, a range of aliphatic and aromatic groups have been incorporated at different sequences in the sequence-defined oligomer. This SDP platform has further been advanced by two ways: (i) multiple approaches for postsynthetic modification of SDP and (ii) increasing the chain length in a single step.

Organic polymers are widely explored due to their high stability, scalability, and more facile modification properties. We developed cost-effective dithiocarbamate-based organic polymers synthesized using diamides, carbon disulfide, and diamines to apply for environmental remediation. The sequestration of radioiodine is a serious concern to tackle when dealing with nuclear power for energy requirements. However, many of the current sorbents have the problem of slower adsorption for removing iodine. In this report, we discuss the utilization of an electron-rich dithiocarbamate-based organic polymer for the removal of iodine in a very short time and with high uptake. Our material showed 2.8 g/g uptake of vapor iodine in 1 h, 915.19 mg/g uptake of iodine from cyclohexane within 5 s, 93% removal of saturated iodine from water in 1 min, and 1250 mg/g uptake of triiodide ions from water within 30 s. To the best of our knowledge, the iodine capture was faster than previously observed for any existing material. The material was fully recyclable when applied for up to four cycles. Hence, this dithiocarbamate-based polymer can be a promising system for the fast removal of various forms of iodine and, thus, enhance environmental security.

A novel class of organic polymer (OP) with customizable functional groups in the backbone and side-chain was designed and synthesized to remove toxic Hg2+ ions from contaminated water within 30...

The emerging paradigm shift from ‘one molecule, one target, for one disease’ towards ‘multi-targeted small molecules’ has paved an ingenious pathway in drug discovery in recent years. This idea has been extracted for the investigation of competent drug molecules for the unprecedented COVID-19 pandemic which became the greatest global health crisis now. Perceiving the importance of organosulfur compounds against SARS-CoV-2 from the drugs under clinical trials, a class of organosulfur compounds effective against SARS-CoV were selected and studied the interaction with multiple proteins of the SARS-CoV-2. One compound displayed inhibition against five proteins (both structural and non-structural) of the virus namely, main protease, papain-like protease, spike protein, helicase and RNA dependent RNA polymerase. Consequently, this compound emanates as a potential candidate for treating the virulent disease. The pharmacokinetics, ADMET properties and target prediction studies carried out in this work further inflamed the versatility of the compound and urge to execute <i>in-vitro</i> and <i>in-vivo</i> analysis on SARS-CoV-2 in the future.<br>