This paper presents an analysis of the advantages, limitations, ethical considerations, future prospects, and practical applications of ChatGPT and artificial intelligence (AI) in the healthcare and medical domains. ChatGPT is an advanced language model that uses deep learning techniques to produce human-like responses to natural language inputs. It is part of the family of generative pre-training transformer (GPT) models developed by OpenAI and is currently one of the largest publicly available language models. ChatGPT is capable of capturing the nuances and intricacies of human language, allowing it to generate appropriate and contextually relevant responses across a broad spectrum of prompts. The potential applications of ChatGPT in the medical field range from identifying potential research topics to assisting professionals in clinical and laboratory diagnosis. Additionally, it can be used to help medical students, doctors, nurses, and all members of the healthcare fraternity to know about updates and new developments in their respective fields. The development of virtual assistants to aid patients in managing their health is another important application of ChatGPT in medicine. Despite its potential applications, the use of ChatGPT and other AI tools in medical writing also poses ethical and legal concerns. These include possible infringement of copyright laws, medico-legal complications, and the need for transparency in AI-generated content. In conclusion, ChatGPT has several potential applications in the medical and healthcare fields. However, these applications come with several limitations and ethical considerations which are presented in detail along with future prospects in medicine and healthcare.
Graphitic carbon nitride (g-C3N4) has been proposed as a promising two-dimensional semiconducting materials and has shown the various applications in the field of photocatalyst due to its thermally stable and...
Due
to the pharmaceutical, biological, physical, and chemical properties
of fluorinated compounds and 1,4-NADH/NADPH, these species have attracted
a lot of attention from researchers across the chemical society. Despite
their crucial significance, present methods of regenerating cofactors
(1,4-NADH/NADPH) as well as inserting fluorine into organic compounds
suffer from ruthless drawbacks. Herein, we designed a highly efficient
S-gC3N4@Fe2O3/LC photocatalyst,
and its in situ generations were accomplished by calcinations of Fe2O3, melamine (M), thiophenol (T), and lignin carbon
(LC). The Fe2O3 part performs similar to an
additional light harvester, gifting utmost photo-generated electrons,
whereas the carbon part bridges a “thoroughfare” to
make easy electron transfer from Fe2O3 to S-gC3N4 (Schemes 1 and 2). Therefore, the newly designed
S-gC3N4@Fe2O3/LC photocatalyst
is more efficient for the generation and regeneration of the C(sp3)–F bond and 1,4-NADH/NADPH due to its surface active
sites and defects.
<p>The
sudden outburst of Coronavirus disease (COVID-19) has left the entire world to
a standstill. COVID-19 is caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2). As per the report from the WHO, more than 4.5
million people have been infected by SARS-CoV-2 with more than 3,00,000 deaths across
the globe. As of now, there is no therapeutic drug or vaccine approved for the
treatment of SARS-CoV-2 infection. Hence, the outbreak of COVID-19 poses a
massive threat to humans. Due to the time taking process of new drug design and
development, drug repurposing might be the only viable solution to tackle
COVID-19. RNA‐dependent RNA polymerase (RdRp) catalyzes SARS-CoV-2 RNA
replication, <i>i.e.</i> the synthesis of
single-stranded RNA genomes, an absolutely necessary step for the survival and
growth of the virus. Thus, RdRp is an obvious target for antiviral drug design.
Interestingly, several plant-derived polyphenols have been shown to inhibit
enzymatic activities of RdRp of various RNA viruses including polio-virus type
1, parainfluenza virus type 3, and respiratory syncytial virus etc. More
importantly, natural polyphenols have been used as a dietary supplementation
for humans for a long time and played a beneficial role in immune homeostasis.
Therefore, we were curious to study the binding of dietary polyphenols with
RdRp of SARS-CoV-2 and assess their potential as an effective therapy for
COVID-19. In this present work, we made a library of twenty potent polyphenols that
have shown substantial therapeutic effects against various diseases. The
polyphenols were successfully docked in the catalytic pocket of RdRp of SARS-CoV
and SARS-CoV-2, and detailed studies on ADME prediction, toxicity prediction
and target analysis were performed. The study reveals that EGCG, quercetagetin,
and myricetin strongly bind to the active site of SARS-CoV-2 RdRp. Our studies
suggest that EGCG, quercetagetin, and myricetin can inhibit RdRp and represent
an effective therapy for COVID-19. </p>
Covalent perylene frameworks (CPFs) with melamine linkages have newly received rising interest for a variety of applications because of nitrogen‐rich content and high stability. Herein, we account a new simple strategy to in situ attain nitrogen‐rich covalent perylene frameworks (NRCPFs) as highly active photo platforms for in situ bond formation between aryldiazonium salts and heteroarenes (C–H bond arylation) through the controlled photoredox route.
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