Background
The prevalence of idiopathic membranous nephropathy (IMN) is increasing worldwide and the gut microbiota is recognized to play a role in its pathology. The aim of this study was to understand the involvement of the gut–kidney axis in IMN by analyzing the composition of the gut microbiota of biopsy-proven IMN patients compared with healthy controls (HC).
Methods
Fecal samples from 30 patients with IMN diagnosed by renal biopsy and 30 healthy co-residents (control group) were collected for analysis in the Nephrology Department of the Second Affiliated Hospital of Harbin Medical University. The microbiota composition was analyzed by a 16S rRNA microbial profiling approach.
Results
The results indicated that the α- and β-diversity of IMN patients differed significantly from those of the HC groups (P < 0.05). At the phylum level, IMN patients showed an increased abundance of Proteobacteria but a reduced abundance of Bacteroidota compared with the HC group. Actinobacteriota abundance showed a strong negative correlation with the estimated glomerular filtration rate. At the genus level, Faecalibacterium, Agathobacter, and Bacteroides were less abundant in the IMN group than in the HC group (LDA score > 2). Abundant bacterial functions related to lipid metabolism were observed among IMN group.
Conclusion
Patients with IMN appear to have an altered gut microbiome, which could provide reference for future research on the interaction mechanism between the intestinal flora and IMN.
The hypopermeability and hypoxia in the tumor milieu are important factors that limit multiple treatments. Herein, the reactive oxygen species (ROS)-triggered self-assembled nanoparticles (RP-NPs) was constructed. The natural small molecule Rhein (Rh) was encapsulated into RP-NPs as a sonosensitizer highly accumulated at the tumor site. Then highly tissue-permeable ultrasound (US) irradiation induced apoptosis of tumor cells through the excitation of Rh and acoustic cavitation, which prompted the rapid production of large amounts of ROS in the hypoxic tumor microenvironment. In addition, the thioketal bond structures in the innovatively designed prodrug LA-GEM were triggered and broken by ROS to achieve rapid targeted release of the gemcitabine (GEM). Sonodynamic therapy (SDT) increased the tissue permeability of solid tumors and actively disrupted redox homeostasis via mitochondrial pathways to kill hypoxic tumor cells, and the triggered response mechanism to GEM synergistically amplified the effect of chemotherapy. The chemo-sonodynamic combinational treatment approach is highly effective and noninvasive, with promising applications for hypoxic tumor elimination, such as in cervical cancer (CCa) patients who want to maintain their reproductive function.
An originality hibrid nanostructure of MoSe2 nanosheets developed in the vertical direction in two-dimensional (2D) mesoporous nanosheets surface of sisal fiber activated carbon (MoSe2⊥SFAC) was obtained through hydrothermal and annealed processes. The microscopic
size is about 10 nm and 1-nm-thick MoSe2 nanosheets. The novel nanostructure of MoSe2⊥SFAC shows a high specific surface area and mesoporous feature, which displays great application prospects in lithium ion batteries (LIBs). The MoSe2⊥SFAC electrode
remains a detailed discharging capacity reaching 501.3 mAh g-1 at 0.1 A g-1 after 50 cycles, and 224.6 mAh g-1 at 1 A g-1 over 500 cycles, with corresponding coulombic efficiency closing to 100%. In contrast to the pure sisal fiber activated carbon,
MoSe2⊥SFAC has a higher lithium ion diffusion coefficient, thus ensuring the rapid transmission of lithium ions.
Although Alfred Lothar Wegener proposed his continental drift hypothesis more than 100 years ago, there has been constant contention regarding the driving source of plate motions. The current geodynamic theory is mainly based on traditional mechanics. The crust is extremely thin in comparison to the earth's radius, which may be caused by a more complex mechanical system: the mechanics of shells. The mechanics of shells reveals the mechanical effect of the tide-generating force on the earth's crust. We present a formula that can be used to calculate the membrane stress resulting from the fluctuation of the mantle tide wave in the crust and estimate its magnitude. Although the tidal force is small, the membrane stress is high. Our investigation suggests that the membrane stress is the fundamental reason for rifting and rupture processes at mid-ocean ridges. It is thus the dynamic source for seafloor spreading and plate motion, which offers a reasonable interpretation of various significant problems that are unexplained by mantle convection theory. And there must be the plate tectonics affected by the tidal force is in the terrestrial planets or other celestial bodies.
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