The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World Health Organisation. Among these compounds, 3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile had the highest activity, with LC(50) = 6.64 microg ml(-1).
The reaction between trihaloisocyanuric acids and alkynes in the presence of acetic acid provides an efficient methodology for preparation of β-haloenol acetates in yields ranging from 34 to 94%, depending on the halogen and alkynes used. This methodology provides an alternative to typical procedures, which usually employ metal catalysis and are limited to terminal alkynes.
Halofluorination of Alkenes Using Trihaloisocyanuric Acids and HF·Pyridine. -The reaction proceeds regio-and stereoselectively to give the Markovnikov-type products. In the case of cyclohexenes (VI), trans isomers are obtained. -(CRESPO, L. T. C.; RIBEIRO, R. D. S.; DE MATTOS*, M. C. S.; ESTEVES, P. M.; Synthesis
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