ChemInform Abstract: Halofluorination of Alkenes Using Trihaloisocyanuric Acids and HF·Pyridine.

Abstract

Halofluorination of Alkenes Using Trihaloisocyanuric Acids and HF·Pyridine. -The reaction proceeds regio-and stereoselectively to give the Markovnikov-type products. In the case of cyclohexenes (VI), trans isomers are obtained. -(CRESPO, L. T. C.; RIBEIRO, R. D. S.; DE MATTOS*, M. C. S.; ESTEVES, P. M.; Synthesis

Monofluorination of Organic Compounds: 10 Years of Innovation

“…Esteves, de Mattos and co-workers developed a variant using trihaloisocyanuric acids ( 9 ), easily handled solids, instead of N -halosuccinimides (Scheme ) . Using this protocol, fluorinated cyclohexanes and benzylic fluorides could be synthesized with a Markovnikov regioselectivity and following an anti-addition in the case of cyclohexene derivatives.…”