Facebook is a popular social networking site. It, like many other new technologies, has potential for teaching and learning because of its unique built-in functions that offer pedagogical, social and technological affordances. In this study, the Facebook group was used as a learning management system (LMS) in two courses for putting up announcements, sharing resources, organizing weekly tutorials and conducting online discussions at a teacher education institute in Singapore. This study explores using the Facebook group as an LMS and the students' perceptions of using it in their courses. Results showed that students were basically satisfied with the affordances of Facebook as the fundamental functions of an LMS could be easily implemented in the Facebook group. However, using the Facebook group as an LMS has certain limitations. It did not support other format files to be uploaded directly, and the discussion was not organized in a threaded structure. Also, the students did not feel safe and comfortable as their privacy might be revealed. Constraints of using the Facebook group as an LMS, implications for practice and limitations of this study are discussed. Practitioner notesWhat is already known about this topic • Facebook has been popularly used by tertiary students, but many students do not want their teachers to be friends on Facebook • Teacher's self-disclosure on Facebook can promote classroom atmosphere, teacher's credibility and student-teacher relationship • Commercial learning management systems (LMSs) have limitations What this paper adds • The Facebook group can be used an LMS as it has certain pedagogical, social and technological affordances • Students are satisfied with the way of using the Facebook group as an LMS

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2-P(MIs)25/TMZ) to achieve synergistic effects against glioma. This A2-P(MIs)25/TMZ display highly promising advantages: (1) a hydrophobic P-(MIs)25 core where poorly water-soluble TMZ can be encapsulated; (2) nitro groups of the hydrophobic P-(MIs)25 core that are converted into hydrophilic amino groups (P(NH 2 s)25) under low oxygen conditions to mimic the oxygen-increased sensitization to RT; (3) a lipid monolayer at the interface of the core and the shell to modify the A2 (a specific ligand for low-density lipoprotein receptor-related protein-1 (LRP-1), which are expressed in the blood-brain barrier (BBB) and human glioma cells), thereby enhancing the drug encapsulation efficiency in glioma. These nanoparticles appear as a promising and robust nanoplatforms for TMZ and hypoxic cell radiosensitization delivery.

Mapping landscape spaces by means of manual and modern technology enables landscape architects to describe, understand, and interpret spatial-visual properties of landscape. This can help to strengthen the body of knowledge of spatial design in landscape architecture through measurement and visualization of common concepts in the field, as well as through the possibility to explore spatial-visual landscape features that was not possible before. Despite the wide ranging possibilities and the methods available for mapping landscape spaces, there is evidence that its potential is often still underutilized mainly due to a lack of awareness. This paper aims to contribute to the increase of awareness by providing an overview of mapping methods and tools that can be used to study spatial-visual characteristics in the field of landscape architecture, and show the potentialities of its application by brief examples. This paper introduces six categories of mapping methods: compartment analysis, 3D landscapes, grid cell analysis, visibility analysis, landscape metrics, and eye-tracking analysis. These methods are used to explore, for spatial design in landscape architecture, crucial spatial-visual categories sequence, orientation, continuity, and complexity in an analogue and digital way. The Vondelpark, a well-known urban park in the Netherlands, is used to exemplify how the spatial features can be mapped by means of the mapping methods.

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Building on the mystery/complexity/legibility/coherence model of Kaplan and Kaplan (1989) and up-to-date landscape visualization techniques, this paper presents a case study analyzing people’s aesthetic preferences for scenes with varying levels of enclosure created through vegetation. Participants were asked to view 48 computer-generated urban park scenes with different levels of enclosure and to rate them for three aesthetic preference factors: coherence, complexity, and legibility. The results are as follows: (1) If the visual and/or physical setting is enclosed, participants will give lower ratings for legibility than in open scenes. (2) Physically open scenes are rated as more coherent than physically enclosed scenes. (3) Participants rate complexity for physically enclosed scenes lower than for physically open scenes. It is concluded that enclosure as a predictor variable for landscape preference has a practical significance for future urban landscape research and designs.