Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,c haracterized by an aberrant metabolic phenotype with high metastatic capacity, resulting in poor patient prognoses and low survival rates.W e designed as eries of novel Au III cyclometalated prodrugs of energy-disrupting Type II antidiabetic drugs namely,m etformin and phenformin. Prodrug activation and release of the metformin ligand was achieved by tuning the cyclometalated Au III fragment. The lead complex 3met was 6000-fold more cytotoxic compared to uncoordinated metformin and significantly reduced tumor burden in mice with aggressive breast cancers with lymphocytic infiltration into tumor tissues.These effects was ascribed to 3met interfering with energy production in TNBCs and inhibiting associated pro-survival responses to induce deadly metabolic catastrophe.

Highly cytotoxic AuI-dithiocarbamate complexes were designed to induce severe integrative stress in ovarian cancer cells, leading to the surface exposure of calreticulin, which is a first step in the activation of immune system.

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LSM with XL probe is feasible in almost two-thirds of morbidly obese patients with a BMI ≥50 kg/m(2). Reliable prediction of advanced fibrosis appears to be possible even if formal criteria of successful measurements are not met.

The solubilizing side-groups of solution-processable π-conjugated organic semiconductors affect both the crystal structure and microstructure of the respective thin films and thus charge-carrier mobility in devices.

Precisec ontrol of the selectivity in organic synthesis is importantt oa ccess the desired molecules. We demonstrate ar egiospecific annulation of unsymmetrically substituted 1,2-di(arylethynyl)benzened erivatives for ag eometrycontrolled synthesis of linear bispentalenes, which is one of the promisings tructures for materials cience.Ag old-catalyzed annulation of unsymmetrically substituted 1,2-di(arylethynyl)benzene could produce two isomeric pentalenes, but both electronic and steric effectso nt he aromatics at the terminal position of the alkyne prove to be crucial for the selectivity;e speciallyaregiospecific annulationw as achieved with sterically blockeds ubstituents;n amely,2 ,4,6-trimetylb enzene or 2,4-dimethyl benzene. This approache nables the geometrically controlled synthesis of linear bispentalenes from 1,2,4,5-tetraethynylbenzeneo r2 ,3,6,7-tetraethynylnaphthalene. Moreover,t he annulation of as eries of tetraynesw ith ad ifferent substitution pattern regioselectively provided the bispentalene scaffolds.Ac omputational study revealed that this is the result of ak inetic control induced by the bulky NHC ligands.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,c haracterized by an aberrant metabolic phenotype with high metastatic capacity, resulting in poor patient prognoses and low survival rates.W e designed as eries of novel Au III cyclometalated prodrugs of energy-disrupting Type II antidiabetic drugs namely,m etformin and phenformin. Prodrug activation and release of the metformin ligand was achieved by tuning the cyclometalated Au III fragment. The lead complex 3met was 6000-fold more cytotoxic compared to uncoordinated metformin and significantly reduced tumor burden in mice with aggressive breast cancers with lymphocytic infiltration into tumor tissues.These effects was ascribed to 3met interfering with energy production in TNBCs and inhibiting associated pro-survival responses to induce deadly metabolic catastrophe.

No abstract