Abstract. The purpose of the present study was to evaluate the anti-fatigue and anti-hypoxic effects of Lycium barbarum polysaccharides (LBP) in mice. The mice were randomly divided into four groups, a control group and three treatment groups. The treated groups received different doses of LBP (125, 250 and 500 mg/kg body) by gavage every day for 28 days, while the control group received distilled water. Forced swimming test and normobaric hypoxia test were conducted on the final day of experimentation. The results showed that LBP could extend the exhaustive swimming time, decrease the blood lactic acid (BLA) and serum urea nitrogen (SUN) levels, and increase liver and muscle glycogen contents in forced swimming test. Meanwhile, LBP could extend hypoxic survival time in normobaric hypoxia test. This indicated that LBP had anti-fatigue and anti-hypoxic effects.
Abstract. Oxidative stress has been proposed as an important pathogenic factor in diabetic wound complications. This study investigated the effect of polysaccharides from Radix Astragali (RAP) on alloxan-induced oxidative stress in diabetic mice. Diabetic mice were randomly divided into five groups: diabetic control, positive drug control, low, moderate, and high-dose RAP treated group. Meanwhile, normal mice were used as the control. RAP treated group received different doses of RAP (100, 200, and 400 mg/kg) via oral gavage once a day for 4 weeks. The effects of RAP on blood glucose, main antioxidant enzymes and malonaldehyde (MDA) were investigated. The results showed that RAP significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in liver and kidney, while decreasing blood glucose levels and MDA levels in liver and kidney in mice. These findings demonstrate that RAP possesses hypoglycemic and protective effect on alloxan-induced oxidative stress in diabetic mice.
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