Rationale:Among patients with post-transplant lymphoproliferative disorder (PTLD), there is a high incidence of immunosuppressed transplant recipients. It is necessary to make an early diagnosis to increase the likelihood of a good prognosis.Patient concerns:We report a case of a 54-year-old female patient who developed PTLD after liver and kidney transplantation.Diagnoses:We aimed to analyze the standard diagnosis and follow-up of PTLD with imaging. Radiologists need to be familiar with all imaging modalities when dealing with PTLD, including ultrasonography, computed tomography, magnetic resonance imaging, positron-emission tomography/computed tomography.Interventions:The initial treatment included both reduction of immunosuppression and rituximab. Then the treatment strategy changed to rituximab and chemotherapy. Finally, the treatment strategy combined glucocorticoid therapy.Outcomes:The patient was in a stable condition at the 3-month follow-up.Lessons:Systematic evaluation of the various imaging modalities, treatment options, and prognoses of PTLD in renal allografts suggested that in cases with a poor prognosis, the proper imaging modalities provide essential information with regard to the determination of the appropriate treatment.
Epstein-Barr virus (EBV) associated lymphoproliferative diseases (LPDs) cover a wide range of lymphocytes disorders spanning B, T, and NK cells. The classification of Epstein-Barr virus (EBV) associated lymphoproliferative disease (LPD) is evolving. We report a 63-year-old male patient with EBV-associated T/B cell LPD diagnosed by pathological biopsy of lymph nodes, which is a new type of EBV-associated LPD has not been reported previously. Because of its rarity, standard treatment has not been established. This patient showed rapid remission of the disease after combination chemotherapy with rituximab, which provided an evidence supporting the use of rituximab and chemotherapy combination in EBV-associated T/B cell LPD treatment.
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