A Case of EBV-associated T/B Cell Lymphoproliferative Disease Successfully Treated with R-CVP

Abstract

Epstein-Barr virus (EBV) associated lymphoproliferative diseases (LPDs) cover a wide range of lymphocytes disorders spanning B, T, and NK cells. The classification of Epstein-Barr virus (EBV) associated lymphoproliferative disease (LPD) is evolving. We report a 63-year-old male patient with EBV-associated T/B cell LPD diagnosed by pathological biopsy of lymph nodes, which is a new type of EBV-associated LPD has not been reported previously. Because of its rarity, standard treatment has not been established. This patient showed rapid remission of the disease after combination chemotherapy with rituximab, which provided an evidence supporting the use of rituximab and chemotherapy combination in EBV-associated T/B cell LPD treatment.