With rapid advancements in sensing, networking, and computing technologies, recent years have witnessed the emergence of cyber-physical systems (CPS) in a broad range of application domains. CPS is a new class of engineered systems that features the integration of computation, communications, and control. In contrast to general-purpose computing systems, many cyber-physical applications are safety-cricial. These applications impose considerable requirements on quality of service (QoS) of the employed networking infrastruture. Since IEEE 802.15.4 has been widely considered as a suitable protocol for CPS over wireless sensor and actuator networks, it is of vital importance to evaluate its performance extensively. Serving for this purpose, this paper will analyze the performance of IEEE 802.15.4 standard operating in different modes respectively. Extensive simulations have been conducted to examine how network QoS will be impacted by some critical parameters. The results are presented and analyzed, which provide some useful insights for network parameter configuration and optimization for CPS design.

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A water-soluble PTP1B inhibitor, named FYGL-a, was fractionated for structure investigation and bioactivity evaluation. FYGL-a is an ingredient of a reported antihyperglycemia extract from Ganoderma Lucidum fruiting bodies. Composition analysis indicated that FYGL-a was a 100.2 kDa acidic proteoglycan, consisting of 85 ± 2% heteropolysaccharide chain with rhamnose, galactose, glucose, and glucuronic acid residues in a mole ratio of 1.0:3.7:3.9:2.0, and the 15 ± 2% protein moiety of FYGL-a was covalently bonded to the polysaccharide chain in O-linkage type via threonine residues. The complete sequence of FYGL-a was characterized systematically by periodate oxidation, Smith degradation, methylation analysis, (1)H & (13)C 1D NMR, and 2D NMR (HSQC, HMBC, NOESY, COSY, & TOCSY). The chemical structure of FYGL-a was determined as following, which may play special role in the competitive inhibition of PTP1B and antihyperglycemia potency.

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Background: In the time since primary care was implemented in China in 2009, programs of promoting residents signing with family doctor services have been key. However, there has been a lack of effective evaluation of its implementation. Methods: We used mixed methods for evaluating existing measures of facilitating signing with family doctors in Shanghai. Based on the Donabedian model, qualitative informant interviews were conducted to obtain experts' evaluations in aspects of team construction (structure) and innovative solutions for promoting and supervising signings (process). Quantitative data were used to analyse the utilization situation (outcome) from "Shanghai Family Doctor Signing Data Platform". Results: Measures of signing with family doctors in Shanghai have functioned well, but there is still a lack of sufficient family doctors and specialists, including paediatricians and gynaecologists. Although proportions of the key population (average=62.59%) and the elderly population (>65 years) (average=78.10%) who had signed with family doctors were relatively high, the proportion of the permanent resident population (average=29.36%) who had signed with family doctors was low from 2017 to 2020 in Shanghai. The proportions of residents seeking medical advice in signed community health centres in outskirts (71.08%) were higher than those in suburbs (63.51%) and urban areas (53.49%), whereas the proportion of those seeking medical advice from recommended multiple medical institutions were similarly low in urban areas, outskirts and suburbs. Conclusion:The practice of facilitate signing with family doctors in Shanghai has increased. However, we showed that numbers of family doctors were relatively low, and there remains a need for more experienced gynaecology and paediatrics professionals, compared with Western countries. Additionally, efforts should be made to increase proportions of residents who utilize the program, especially in urban areas, and seek medical services in contracted group hospitals and community health centres.