Main observation and conclusion
Herein, we report a highly chemo‐ and regioselective vicinal trifunctionalization of aryl iodides by palladium/norbornene (Pd/NBE) catalysis. The key feature of this new method is the introduction of two distinct nitrogen and carbon electrophiles, with a large gap in reactivity, for ortho‐unsubstituted aryl iodides via an intermolecular and intramolecular C―H functionalization, respectively. Eight types of ipso terminations can be coupled with both ortho‐amination and ortho‐alkylation, affording a variety of polysubstituted benzoheterocyclic scaffolds. Silicon‐tethered substrates can lead to polyfucntional arenes via a single‐step operation. Noteworthy, these products exhibit full‐color‐tunable strong fluorescence emissions with large Stokes shifts, and product 7r can serve as a fluorescent probe to specifically target lysosome in living cells.
Polar disconnection of the C(sp3)−N bond of N,N‐dialkyl‐substituted tertiary amines via ammonium species conventionally favored the loss of the smaller alkyl group by an SN2 displacement, while selective C(sp3)−N bond cleavage by cutting off the larger alkyl group is still underdeveloped. Herein, we present a novel Pd0‐catalyzed [2+2+1] annulation, proceeding through an alkyne‐directed palladacycle formation and consecutive diamination with a tertiary hydroxylamine by cleaving its N−O bond and one C(sp3)−N bond, for the rapid assembly of tricyclic indoles in a single‐step transformation. Noteworthy, experimental results indicated that large tert‐butyl and benzyl groups were selectively cleaved via an SN1 pathway, in the presence of a smaller alkyl group (Me, Et, iPr). Under the guidance of this new finding, tricyclic indoles bearing a removable alkyl group could be exclusively obtained by using a (α‐methyl)benzyl/benzyl or tert‐butyl/2‐(methoxycarbonyl)ethyl mixed amino source.
Herein we describe a palladium/norbornene catalyzed trifunctionalization of ortho-unsubstituted aryl iodides via a highly chemoselective cascade process involving intermolecular ortho acylation/intramolecular ortho alkylation/ipso alkenylation. This approach provides a modular and...
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