A novel supramolecular framework featuring aluminosilicate Linde type A zeolite topology was assembled by using Fe4 coordination cages as building blocks.

Four pairs of enantiomers of water-stable tetrahedral metal-organic cages [Ni4L6](8+) were facilely synthesized. They efficiently stabilized antiparallel G-quadruplex DNA with moderate enantioselectivity, and displayed promising cytotoxicity against the human cancer cell lines HCT116, HepG2 and MCF-7. These results provide a new insight into the rational design of chiral G-quadruplex-based anticancer agents.

Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-β (Aβ) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral Aβ inhibitors using supramolecular metal-organic cages.