Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation

Abstract

Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-β (Aβ) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral Aβ inhibitors using supramolecular metal-organic cages.

Syntheses, structures, and magnetic properties of the lanthanide complexes of imidazole-substituted nitronyl nitroxide biradicals

“…Ln(hfac) 3 ·2H 2 O and the starting materials 1,2-di(imidazole-2-carboxaldehyde)ethane and 1,4-di(imidazole-2-carboxaldehyde)butane were prepared according to the reported method. 22 Powder XRD patterns were recorded on a Bruker D8X diffractometer equipped with a monochromatized Cu-Kα ( λ = 0.15418 nm) radiation source at room temperature, and the data were collected in the range of 5° ≤ 2 θ ≤ 50° on the ground crystalline samples for all complexes (Fig. S1†).…”

Artificial Chiral Interfaces against Amyloid-β Peptide Aggregation: Research Progress and Challenges

“…Gu et al designed and synthesized a series of chiral cages as inhibitors against Aβ aggregation with a certain extent of enantioselectivity. 74 The experimental results disclosed that the chiral tetrahedral nickel(II) coordination cages enantioselectively bind to the Aβ peptide through electrostatic interaction and π−π stacking. The design of the novel supramolecular complexes provides new insights on the size, charge, functional groups, stereoselectivity, and other factors integrated into the design of chiral Aβ aggregation inhibitors.…”

“…Gu et al. designed and synthesized a series of chiral cages as inhibitors against Aβ aggregation with a certain extent of enantioselectivity . The experimental results disclosed that the chiral tetrahedral nickel­(II) coordination cages enantioselectively bind to the Aβ peptide through electrostatic interaction and π–π stacking.…”

Chiral superstructures from homochiral Zn2+, Co2+, Fe2+‐2,6‐bis (aryl ethylimine)pyridine complexes

“…In the design and the synthesis of chiral ligands that, upon coordination with metal ions, can induce high stereoselectivity at a supramolecular level, Schiff bases with stereogenic centres in their backbones have been extensively used as powerful tools for the spontaneous generation of chiral superstructures. Typically, these chiral Schiff bases are obtained by condensation between aldehydes and chiral primary amines, and, among the most frequently used chiral amines, one can include enantiomeric pairs of R‐(+)‐1‐/S‐(−)‐1‐phenylethylamine and R‐(+)‐1‐/S‐(−)‐1‐naphthylethylamine …”