This study assessed the accuracy of telephone and Internet surveys of probability samples and Internet surveys of non-probability samples of American adults by comparing aggregate survey results against benchmarks. The probability sample surveys were consistently more accurate than the non-probability sample surveys, even after post-stratification with demographics. The non-probability sample survey measurements were much more variable in their accuracy, both across measures within a single survey and across surveys with a single measure. Post-stratification improved the overall accuracy of some of the nonprobability sample surveys but decreased the overall accuracy of others.

Three studies tested the hypothesis that people may turn to materialism when they face uncertainties in modern life. Study 1 showed that anomie and self-doubt are significant predictors of materialistic orientations; other plausible antecedents have less predictive value. In Study 2, participants experiencing chronic selfdoubt showed a higher level of materialism if they were primed to experience doubt and insecurity. In Study 3, participants with chronic perceptions of anomie showed a higher level of materialism if they were primed with the concept of normlessness. Together, these three studies show that some people turn to materialism when they experience uncertainty within the self (self-doubt) or perceive uncertainty relating to society (anomie). ᭧

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies have shown a dark side of HO-1, in which HO-1 acts as a critical mediator in ferroptosis induction and plays a causative factor for the progression of several diseases. Ferroptosis is a newly identified iron- and lipid peroxidation-dependent cell death. The critical role of HO-1 in heme metabolism makes it an important candidate to mediate protective or detrimental effects via ferroptosis induction. This review summarizes the current understanding on the regulatory mechanisms of HO-1 in ferroptosis. The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator. Despite the dark side that is related to cell death, there is a prospective application of HO-1 to mediate ferroptosis for cancer therapy as a chemotherapeutic strategy against tumors.

In a national field experiment, the same questionnaires were administered simultaneously by RDD telephone interviewing, by the Internet with a probability sample, and by the Internet with a nonprobability sample of people who volunteered to do surveys for money. The probability samples were more representative of the nation than the nonprobability sample in terms of demographics and electoral participation, even after weighting. The nonprobability sample was biased toward being highly engaged in and knowledgeable about the survey's topic (politics). The telephone data manifested more random measurement error, more survey satisficing, and more social desirability response bias than did the Internet data, and the probability Internet sample manifested more random error and satisficing than did the volunteer Internet sample. Practice at completing surveys increased reporting accuracy among the probability Internet sample, and deciding only to do surveys on topics of personal interest enhanced reporting accuracy in the nonprobability Internet sample. Thus, the nonprobability Internet method yielded the most accurate self-reports from the most biased sample, while the probability Internet sample manifested the optimal combination of sample composition accuracy and self-report accuracy. These results suggest that Internet data collection from a probability sample yields more accurate results than do LINCHIAT CHANG is an independent contractor in San Francisco, CA, USA.