Multivalent O-antigen polysaccharide glycoconjugate vaccines are under development to prevent invasive infections caused by pathogenic
Enterobacteriaceae
. Sequence type 131 (ST131)
Escherichia coli
of serotype O25b has emerged as the predominant lineage causing invasive multidrug-resistant extraintestinal pathogenic
E. coli
(ExPEC) infections. We observed the prevalence of
E. coli
O25b ST131 among a contemporary collection of isolates from U.S. bloodstream infections from 2013 to 2016 (
n
= 444) and global urinary tract infections from 2014 to 2017 (
n
= 102) to be 25% and 24%, respectively.
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