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Tacrolimus was comparable with cyclophosphamide for inducing renal remission of PMN patients within 1 year, but the long-term effects need to be investigated. The cyclophosphamide group had a significantly higher risk of leukopenia, whereas the tacrolimus group had significantly higher rates of tremor. These conclusions need to be further verified.

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When a road vehicle moving on a bridge deck is passing by a bridge tower, the vehicle will be shielded briefly from the crosswind by the bridge tower. This study aimed to apply computational fluid dynamics to explore this special engineering problem for the first time. A stationary vehicle immerged in the wake of a bridge tower was first simulated and compared with wind tunnel test results. By using the dynamic mesh method, the moving of the vehicle passing by a bridge tower was then simulated. The results show that the computed aerodynamic coefficients of the stationary vehicle are generally larger than wind tunnel results. The side force and yawing moment coefficients of the moving vehicle are lower than those of the stationary vehicle. The results also show that the suddenly changing time of aerodynamic forces caused by the tower may be shorter than the average driver reaction time.

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To investigate the safety of road vehicles running on a long-span bridge under high crosswinds, the aerodynamic forces of a moving vehicle-bridge deck system need to be determined. This paper reports the use of computational fluid dynamics (CFD) to simulate the aerodynamic forces on coupled vehicle-bridge deck systems under crosswinds in terms of aerodynamic coefficients. The aerodynamic coefficients of a stationary vehicle-deck system were simulated and then compared with wind tunnel results. A relative velocity method was then used to obtain the aerodynamic forces of a moving vehicle-deck system. The moving effects on the aerodynamic forces on the vehicle-deck system were evaluated. The results show that the movement of the vehicle on the first lane of the bridge deck does affect the aerodynamic coefficients of the bridge deck but has only slight effects on the aerodynamic coefficients of the vehicle if the relative yaw angle to the vehicle is taken into account.

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