In chemodynamic therapy (CDT), real-time monitoring of
reactive
oxygen species (ROS) production is critical to reducing the nonspecific
damage during CDT and feasibly evaluating the therapeutic response.
However, CDT agents that can emit ROS-related signals are rare. Herein,
we synthesize a semiconducting polymer nanoplatform (SPN) that can
not only produce highly toxic ROS to kill cancer cells but also emit
ROS-correlated chemiluminescent signals. Notably, the efficacy of
both chemiluminescence and CDT can be significantly enhanced by hemin
doping (∼10-fold enhancement for luminescent intensity). Such
ROS-dependent chemiluminescence of SPN allows ROS generation within
a tumor to be optically monitored during the CDT process. Importantly,
SPN establishes an excellent correlation of chemiluminescence intensities
with cancer inhibition rates in vitro and in vivo. Thus, our nanoplatform
represents the first intelligent strategy that enables chemiluminescence-imaging-monitored
CDT, which holds potential in assessing therapeutic responsivity and
predicting treatment outcomes in early stages.
Chemodynamic therapy is an emerging tumor therapeutic strategy. However, the anticancer effects are greatly limited by the strong acidity requirements for effective Fenton‐like reaction, and the inevitably “off‐target” toxicity. Herein, we develop an acidity‐unlocked nanoplatform (FePt@FeOx@TAM‐PEG) that can accurately perform the high‐efficient and tumor‐specific catalysis for anticancer treatment, through dual pathway of cyclic amplification strategy. Notably, the pH‐responsive peculiarity of tamoxifen (TAM) drug allows for the catalytic activity of FePt@FeOx to be “turn‐on” in acidic tumor microenvironments, while keeping silence in neutral condition. Importantly, the released TAM within cancer cells is able to inhibit mitochondrial complex I, leading to the upregulated lactate content and thereby the accumulated intracellular H+, which can overcome the intrinsically insufficient acidity of tumor. Through the positive feedback loop, large amount of active FePt@FeOx nanocatalyzers are released and able to access to the endogenous H2O2, exerting the improved Fenton‐like reaction within the more acidic condition. Finally, such smart nanoplatform enables self‐boosting generation of reactive oxygen species (ROS) and induces strong intracellular oxidative stress, leading to the substantial anticancer outcomes in vivo, which may provide a new insight for tumor‐specific cascade catalytic therapy and reducing the “off‐target” toxicity to surrounding normal tissues.
We developed ac yclic amplification method for an organic afterglow nanoreporter for the real-time visualization of self-generated reactive oxygen species (ROS). We promoted semiconducting polymer nanoparticles (PFODBT) as acandidate for emitting near-infrared afterglow luminescence.I ntroduction of ac hemiluminescent substrate (CPPO) into PFODBT (PFODBT@CPPO) resulted in as ignificant enhancement of afterglow intensity through the dual cyclic amplification pathway involving singlet oxygen ( 1 O 2 ). 1 O 2 produced by PFODBT@CPPO induced cancer cell necrosis and promoted the release of damage-related molecular patterns,t hereby evoking immunogenic cell death (ICD)-associated immune responses through ROS-based oxidative stress. The afterglow luminescent signals of the nanoreporter were well correlated with light-driven 1 O 2 generation and anti-cancer efficiency.T his imaging strategy provides an on-invasive tool for predicting the therapeutic outcome that occurs during ROSmediated cancer therapy.
Background: Thyroid carcinoma is the most common endocrine malignancy and a common cancer among the malignancies of head and neck. Noninvasive and convenient biomarkers for diagnosis of papillary thyroid carcinoma (PTC) as early as possible remain an urgent need. The aim of this study was to discover and identify potential protein biomarkers for PTC specifically.
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