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The crystal structure of the theophylline–nicotinamide cocrystal is determined for the first time by using a combined multi-technique approach.

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Graphene oxide (GO) was successfully incorporated into a hybrid lyotropic liquid crystal (LLC) matrix formed by two kinds of surfactants n-dodecyl tetraethylene monoether (C 12 E 4 ) and 1-dodecyl-3-methylimidazolium bromide ionic liquid (C 12 mimBr). By changing the ratios of C 12 E 4 and C 12 mimBr, two types of C 12 E 4 /C 12 mimBr LLC matrixes (lamellar and hexagonal phase) were formed and the effects of the concentration of GO and temperature on the properties of GO/C 12 E 4 /C 12 mimBr LLC composites were systematically investigated by polarized optical microscopy (POM) observations, small-angle X-ray scattering (SAXS) and rheological measurement. Both POM observations and SAXS results indicated that GO can be well-dispersed in the hybrid LLC matrixs at room temperature. Moreover, after the incorporation of GO, the temperature tolerance of

Polymorphism of cocrystals is a fascinating research topic in the field of crystal engineering. For the often employed mechanochemical synthesis approach, the solvent polarity and the stoichiometric ratio of starting materials were previously confirmed as significant variables controlling the polymorphic outcomes. In this study, the 1:1 (THP-AH11) and 1:2 (THP-AH12) theophylline-acesulfame cocrystals were obtained by using mechanochemical method with different synthesis parameters. It was found that the solid form of the mechanochemical product can also be altered by grinding energy and forms of starting materials. All these effect factors are understandable from the point of view of energy mechanism, which modified either the energy barrier or the reaction pathway.