Hipertensi merupakan faktor resiko utama untuk penyakit serebrovaskular seperti stroke, transient ischemic attack, penyakit arteri koroner (infark miokard, angina), gagal ginjal, dementia, dan atrial fibrilasi. Bila penderita hipertensi disertai dengan komplikasi dengan penyakit penyerta tertentu maka akan meningkatkan mortalitas dan morbiditas akibat gangguan kardiovaskularnya tersebut. Kegiatan pengabdian masyarakat ini bertujuan memberikan informasi dan edukasi kepada masyarakat tentang DAGUSIBU dengan harapan dapat mencegah atau menghambat terjadinya komplikasi kardiovaskuler. Pentingnya pemberian informasi dan edukasi tentang penggunaan obat yang benar mempengaruhi tingkat tercapainya tujuan pengobatan. Kegiatan ini diharapkan dapat meningkatkan kepatuhan pasien minum obat. Partisipan pada kegiatan ini adalah seluruh lansia di Posyandu Kelurahan Bandungrejosari Kecamatan Sukun Kota Malang. Metode pendidikan masyarakat mengenai pentingnya kepatuhan minum obat antihipertensi ini diharapkan memberikan manfaat yang cukup efektif. Kartu DAGUSIBU obat ini akan digunakan sebagai media memantau tingkat kepatuhan minum obat antihipertensi. Peserta posyandu yang hadir kegiatan ini terdapat sebanyak 75% yang memiliki tekanan darah tinggi, hanya sekitar 38% yang minum obat antihipertensi. Para peserta posyandu meneriman kartu DAGUSIBU dan dimonitoring kepatuhan minum obat setelah satu bulan. Hal ini terlihat dari jumlah pasien posyandu yang patuh minum obat sebesar 60%. Hasil dari metode ini dapat dikatakan cukup efektif untuk memotivasi masyarakat dalam menggunakan obat-obat antihipertensi secara tertib agar tidak jatuh pada komplikasi kardiovaskuler yang membahayakan.
BackgroundHypertension is a cardiovascular disease which has become a major health problem in Indonesia. Left ventricle hypertrophy is one of the cardiac complications of hypertension that is characterized by thickening of the left ventricle and increasing the mass of cardiac muscle.MethodsThis study was an experimental study with a posttest group design. Twenty-four mice were divided into four groups. The normal group was given distilled water, the negative control group was given L-NAME 1.75 mg/25 g BW/day, the positive control group was given L-NAME 1.75 mg/25 g BW/day + captopril 0.04875 mg/30 g BW/day, and the adjuvant captopril group was given L-NAME 1.75 mg/25 g BW/day + captopril 0.04875 mg/30 g BW/day + curcuma extract 31.25 mg/30 g BW for 30 days.ResultsThe results of one-way analysis of variance (ANOVA) test analysis on the adjuvant treatment of the captopril group revealed no significant effect on cardiac muscle mass (p > 0.05), while the thickness of the left ventricle was significant (p < 0.05).ConclusionsCaptopril-Curcuma group resulted in a decrease of cardiac muscle and the thickness of the left ventricle in male mice with hypertension.
Soluble ST2, is a protein which acts as a decoy receptor for interleukin-33, and served as biomarker associated with left ventricular hypertrophy (LVH). Few data exist in evaluating the effects of anti-hypertensive agents on the role-played form ST2 on regression of LVH. This study was designed to compare the effects of captopril and valsartan on blood pressures, plasma renin and soluble ST2 levels and regression of LVH in hypertensive mice models. Twenty-four male mice (Mus musculus L), were divided into four groups, namely aquadest/control, L-NAME, L-NAME + captopril and L-NAME + valsartan groups respectively. Mice blood pressures were measured on day 14th after induction with L-NAME extract 1.75 mg/25g BW/day (pretreatment) and day 14th post treatment. Levels of plasma renin, sST2, and ventricular wall thicknesses reflecting LVHs, were measured on day 14th post treatment. Administration of L-NAME within 14 days resulted in making mice models to be hypertensive paralleled by an increase of Ventricular wall thickness. Treatment with captopril and valsartan lowered the blood pressures to normal level within the next 14 days. Valsartan and captopril treatment induced a significant decrease of plasma renin level. Valsartan, but not for captopril treatment prevented wall thickness increase (p < 0.05), while plasma sST2 was not able to mirroring this effect. Captopril and valsartan had similar effect in lowering plasma renin level and blood pressure, but sST2 seems to be not involved in LVH regression obtained in hypertensive mice models after blocking renin-angiotensin system.
The search for new drugs to treat cases of infection continues. This is because the microorganisms that cause infection continue to mutate as a form of self-defense which causes resistance to antibiotics. One strategy for finding new drugs is through the exploration of active ingredients derived from plants that have been used empirically by the community. Impatiens balsamina is a plant that has been shown to have antibacterial, antifungal, antipruritic, and anti-allergic characteristics. The ethanol extract of the Impatiens balsamina flower contains secondary metabolites such as naphthoquinones, coumarin derivatives, flavonoids, steroids, quinones, and saponins. This study aimed to obtain the active ingredient of the Impatiens balsamina flower which is used as an herbal medicine in the treatment of infection. A multilevel extraction process was carried out using solvents of different polarity, so that fractions containing nonpolar compounds, semipolar compounds, and polar compounds were obtained. Then, each fraction was tested for antimicrobial potency. Antimicrobial testing in vitro was carried out using the disc diffusion method. The results showed that the secondary metabolites contained in the hexane fraction were terpenoids, flavonoids, polyphenols, and anthraquinone compounds. Secondary metabolites contained in the ethyl acetate fraction were alkaloids, terpenoids, flavonoids, polyphenols, and anthraquinone compounds. Secondary metabolites contained in the ethanol fraction were terpenoids, flavonoids, polyphenols, and anthraquinone compounds. The hexane fraction had the best percentage of inhibition and percentage of effectiveness against Staphylococcus aureus, Escherichia coli, and Candida albicans.
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