Several matrix metalloproteinases (MMPs) and psychological stress are associated with poor cancer prognosis. The current work goal was to determine MMPs’ and stress hormones’ blood concentrations from lung adenocarcinoma (LAC) patients. Patients were divided into the following groups: tobacco smokers (TS), wood smoke-exposed (W), passive smokers (PS), TS exposed to wood smoke (TW), and patients with no recognizable risk factor (N). MMPs, tissue inhibitors of metalloproteinases (TIMPs), adrenaline, noradrenaline, and cortisol blood concentrations were measured by ELISA. Zymography and Western blot assays were performed to determine MMP-2 and MMP-9 active and latent forms. MMP-2, MMP-3, MMP-9, and TIMP-1 blood concentrations, and MMP-9 gelatinase activity were augmented, while MMP-12, MMP-14, and TIMP-2 were diminished in LAC patients. Cortisol was increased in LAC samples. Adrenaline concentrations were higher in W, TS, and TW, and noradrenaline was increased in W and N groups. Positive correlations were observed among cortisol and TIMP-1 (
r
s
=
0.392
) and TIMP-2 (
r
s
=
0.409
) in the W group and between noradrenaline and MMP-2 (
r
s
=
0.391
) in the N group. MMPs’ blood concentration increments can be considered as lung cancer progression markers. Although stress hormones were also augmented, only weak correlations were observed between them and MMPs and TIMPs.
Esta investigación descubre una nuena manera de contar la historia nacional, la escritura dramática con óptica de género, mirada de mujer. Las dramaturgas, dos mexicanas y dos españolas, abordan el drama de la patria, desde diversos géneros, estilos y épocas. Teatro con preocupaciones femeninas y feministas, y anhelos de paz, de convivencia pacífica, de comunidad armoniosa, de denuncia de la desigualdad. Comedia, farsa, tragedias, tragicomedias que transitan por el corredor cultural Iberoamericano y su historia violenta, de violencia contra las mujeres.
Cierta tendencia -en inglés- considera que la Ciencia Ficción escrita en español carece de creatividad y conocimiento científico— tecnológico: “nomenclatura confusa y a exégesis que abusa de imaginarios y narrativa fantástica”. Para rebatir tal visión dogmática y estrecha, esta investigación revela, desde la teoría de la recepción, la trascendencia de la escritura de mujeres en la Ciencia Ficción mexicana y da cuenta del horizonte de expectativas en el ambiente literario.
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