As highlighted by the recent ChemComm web themed issue on ionic liquids, this field continues to develop beyond the concept of interesting new solvents for application in the greening of the chemical industry. Here some current research trends in the field will be discussed which show that ionic liquids research is still aimed squarely at solving major societal issues by taking advantage of new fundamental understanding of the nature of these salts in their low temperature liquid state. This article discusses current research trends in applications of ionic liquids to energy, materials, and medicines to provide some insight into the directions, motivations, challenges, and successes being achieved with ionic liquids today.

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A series of acid-base bifunctional catalysts (ABBCs) that contain one or two Brønsted acidic sites in the cationic part and a Lewis-basic site in the anionic part are used as efficient catalysts for the synthesis of cyclic carbonates by cycloaddition of CO(2) to epoxides, without the use of additional co-catalyst or co-solvent. The effects of the catalyst structures and various reaction parameters on the catalytic performance are investigated in detail. Almost complete conversion can be achieved in 1 h for propylene oxide using [{(CH(2))(3)COOH}(2) im]Br under mild reaction conditions (398 K and 2 MPa). Furthermore, the catalyst can be recycled over five times without substantial loss of catalytic activity. This protocol is found to be applicable to a variety of terminal epoxides, producing the corresponding cyclic carbonates in good yields and high selectivities. A synergistic effect of the acidic and the basic sites as well as suitable hydrogen-bonding strength of ABBCs are considered crucial for the reaction to proceed smoothly. The activities of the ABBCs increase remarkably with increasing carboxylic-acid chain length of the cation. This metal- and solvent-free process thus represents an environmentally friendly process for BTC-catalyzed conversion of CO(2) into value-added chemicals.

Seven new sesquiterpenes (1-7), together with seven known sesquiterpenes, aplysin (8), aplysinol (9), gossonorol (10), 7,10-epoxy-ar-bisabol-11-ol (11), 10-epi-7,10-epoxy-ar-bisabol-11-ol (12), johnstonol (13), and laurebiphenyl (14), have been isolated from the red alga Laurencia tristicha. The structures of new compounds were established as laur-11-en-2,10-diol (1), laur-11-en-10-ol (2), laur-11-en-1,10-diol (3), 4-bromo-1,10-epoxylaur-11-ene (4), cyclolauren-2-ol (5), laurentristich-4-ol (6), and ar-bisabol-9-en-7,11-diol (7) by means of spectroscopic methods including IR, HRMS, and 1D and 2D NMR techniques. Compound 6 possessed a novel rearranged skeleton. All compounds were tested against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8), and HELA cell lines. Laurebiphenyl (14) showed moderate cytotoxicity against all tested cell lines, with IC(50) values of 1.68, 1.22, 1.91, 1.77, and 1.61 microg/mL, respectively. Other compounds were inactive (IC(50) > 10 microg/mL).

Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits potential anti-tumor activity against many tumor cell lines. This study aims to examine the anti-tumor activity of OA on pancreatic cancer cells and its potential molecular mechanism. The results showed that the proliferation of Panc-28 cells was inhibited by OA in a concentration-dependent manner, with an IC50 (The half maximal inhibitory concentration) value of 46.35 µg ml(-1) , as determined by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The cell cycle was arrested in S phase and G2/M phase by OA. The study also showed that OA could induce remarkable apoptosis, evidenced by an increased percentage of early/late apoptotic cells, DNA ladder and nuclear morphology change. Further study revealed that OA could induce Reactive Oxygen Species (ROS) generation, mitochondrial depolarization, release of cytochrome C, lysosomal membrane permeabilization and leakage of cathepin B. The expression of apoptosis-correlated proteins was also affected in cells treated with OA, including activation of caspases-3/9 and cleavage of PARP. Further study confirmed that ROS scavenger vitamin C could reverse the apoptosis induced by OA in Panc-28 cells. Our results provide evidence that OA arrests the cell cycle and induces apoptosis, possibly via ROS-mediated mitochondrial and a lysosomal pathway in Panc-28 cells.

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Two-dimensional CdS micro/nano leaves have been synthesized via a controlled hydrothermal process. The dimensions of the leaves is in the range of 4-6 mm and the thickness of the leaves is 30-50 nm. The surface of the leaves is smooth and composed of several parallel laminar layers with multi-steps. The SAED and HRTEM images indicated that the surface of the leaves was mainly composed of ( 0001) plane and all the leaves had single-crystallinity. The morphology of the as-prepared products could be controlled by adjusting the concentration of hydrofluoric acid (HF). The effects of HF concentration, reaction temperature and time were investigated. A possible formation mechanism is proposed based on the intrinsic crystal structure and selected adsorption processes. In addition, the as-prepared CdS pinnate leaves showed enhanced photocatalytic activity toward hydrogen evolution under visible light irradiation. The efficiency of micro/nano leaves was more than 6 times greater than normal CdS microparticles.

A new lower tungsten divertor has been developed and installed in the EAST superconducting tokamak to replace the previous graphite divertor with power handling capability increasing from <2 MW m−2 to ∼10 MW m−2, aiming at achieving long-pulse H-mode operations in a full metal wall environment with the steady-state divertor heat flux of ∼10 MW m−2. A new divertor concept, ‘corner slot’ (CS) divertor, has been employed. By using the ‘corner effect’, a strongly dissipative divertor with the local buildup of high neutral pressure near the corner can be achieved, so that stable detachment can be maintained across the entire outer target plate with a relatively lower impurity seeding rate, at a separatrix density compatible with advanced steady-state core scenarios. These are essential for achieving efficient current drive with low-hybrid waves, a low core impurity concentration and thus a low loop voltage for fully non-inductive long-pulse operations. Compared with the highly closed small-angle-slot divertor in DIII-D, the new divertor in EAST exhibits the following merits: (1) a much simpler geometry with integral cassette body structure, combining vertical and horizontal target plates, which are more suitable for actively water-cooled W/Cu plasma facing components, facilitating installation precision control for minimizing surface misalignment, achieving high engineering reliability and lowering the capital cost as well; (2) it has much greater flexibility in magnetic configurations, allowing for the position of the outer strike point on either vertical or horizontal target plates to accommodate a relatively wide triangularity range, δ l = 0.4–0.6, thus enabling to explore various advanced scenarios. A water-cooled copper in-vessel coil has been installed under the dome. Five supersonic molecular beam injection systems have been mounted in the divertor to achieve faster and more precise feedback control of the gas injection rate. Furthermore, this new divertor allows for double null divertor operation and slowly sweeping the outer strike point across the horizontal and vertical target plates to spread the heat flux for long-pulse operations. Preliminary experimental results demonstrate the ‘corner effect’ and are in good agreement with simulations using SOLPS-ITER code including drifts. The EAST new divertor provides a test-bed for the closed divertor concept to achieve steady-state detachment operation at high power. Next step, a more closed divertor, ‘sharp-cornered slot’ divertor, building upon the current CS divertor concept, has been proposed as a candidate for the EAST upper divertor upgrade.