Motivation: Increased availability of various genotyping techniques has initiated a race for finding genetic markers that can be used in diagnostics and personalized medicine. Although many genetic risk factors are known, key causes of common diseases with complex heritage patterns are still unknown. Identification of such complex traits requires a targeted study over a large collection of data. Ideally, such studies bring together data from many biobanks. However, data aggregation on such a large scale raises many privacy issues.Results: We show how to conduct such studies without violating privacy of individual donors and without leaking the data to third parties. The presented solution has provable security guarantees.Contact:
jaak.vilo@ut.eeSupplementary information:
Supplementary data are available at Bioinformatics online.
We discuss the widely increasing range of applications of a cryptographic technique called Multi-Party Computation. For many decades this was perceived to be of purely theoretical interest, but now it has started to find application in a number of use cases. We highlight in this paper a number of these, ranging from securing small high value items such as cryptographic keys, through to securing an entire database.
In this paper, we show that it is possible and, indeed, feasible to use secure multiparty computation (SMC) for calculating the probability of a collision between two satellites. For this purpose, we first describe basic floating point arithmetic operators (addition and multiplication) for multiparty computations. The operators are implemented on the Sharemind SMC engine. We discuss the implementation details, provide methods for evaluating example elementary functions (inverse, square root, exponentiation of e, error function). Using these primitives, we implement a satellite conjunction analysis algorithm and give benchmark results for the primitives as well as the conjunction analysis itself.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.