BackgroundThe intracoronary high-thrombus burden during the primary percutaneous
coronary intervention in patients with ST-elevation myocardial infarction
(STEMI) can lead to poor outcomes. Monocytes have been described to play an
important role in thrombotic disorders.ObjectivesThis study aimed to investigate the relationship between admission monocyte
count and angiographic intracoronary thrombus burden in patients receiving
primary percutaneous coronary intervention (PPCI).MethodsA total of 273 patients with acute STEMI who underwent PPCI were enrolled.
The patients were divided into two groups according to the thrombolysis in
myocardial infarction (TIMI) thrombus grade: low-thrombus burden group with
a grade of 0-2 and high-thrombus burden group with a grade of 3-4. The
monocyte count and other laboratory parameters were measured on admission
before PPCI. P-value < 0.05 was considered significant.ResultsThere were 95 patients (34.8%) in the high-thrombus burden group, and 178
patients (65.2%) in the low-thrombus burden group. Patients with
high-thrombus burden had significantly higher admission monocyte count (0.61
± 0.29×109/L vs. 0.53 ±
0.24×109/L, p = 0.021). In multivariate analysis,
monocyte count was the independent predictor of angiographic high-thrombus
burden (odds ratio 3.107, 95% confidence interval [CI]
1.199-7.052, p = 0.020). For the prediction of angiographic high-thrombus
burden, admission monocyte count at a cut-off value of
0.48×109/L yielded 0.59 ROC-AUC (71.9% sensitivity,
46.9% specificity).ConclusionsMonocyte count on admission was an independent clinical predictor of
high-thrombus burden in patients with STEMI undergoing PPCI. Our findings
suggest that admission monocyte count may be available for early risk
stratification of high-thrombus burden in acute STEMI patients and might
allow the optimization of antithrombotic therapy to improve the outcomes of
PPCI.
A b s t r a c t Background:The no-reflow phenomenon during primary percutaneous coronary intervention (pPCI) in patients with ST-elevation myocardial infarction (STEMI) can lead to poor outcomes. It has been shown that the monocytes may be involved in the pathogenesis of coronary artery disease and associated with high risk of myocardial infarction.
Aim:To assess the relation between admission monocyte count and angiographic no-reflow after pPCI.
Methods:A total of 236 patients with acute STEMI, who underwent pPCI, were enrolled. The patients were divided into two groups (no-reflow and normal reflow) based on post-pPCI Thrombolysis in Myocardial Infarction (TIMI) flow grade. No reflow was defined as TIMI flow grades ≤ 2, and normal reflow was defined as TIMI 3 flow grade. The monocyte count and other laboratory parameters were measured on admission before pPCI.
Conclusions:Monocyte count on admission and low haemoglobin concentration were independent clinical predictors of no-reflow following pPCI in patients with STEMI. Our findings suggest that admission monocyte count may be available for early risk stratification of no-reflow after pPCI and might allow the improvement of strategies to prevent this phenomenon.
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