Association of monocyte count on admission with angiographic no-reflow after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Abstract

A b s t r a c t Background:The no-reflow phenomenon during primary percutaneous coronary intervention (pPCI) in patients with ST-elevation myocardial infarction (STEMI) can lead to poor outcomes. It has been shown that the monocytes may be involved in the pathogenesis of coronary artery disease and associated with high risk of myocardial infarction. Aim:To assess the relation between admission monocyte count and angiographic no-reflow after pPCI. Methods:A total of 236 patients with acute STEMI, who underwent pPCI, were enrolled. The patients were divided into two groups (no-reflow and normal reflow) based on post-pPCI Thrombolysis in Myocardial Infarction (TIMI) flow grade. No reflow was defined as TIMI flow grades ≤ 2, and normal reflow was defined as TIMI 3 flow grade. The monocyte count and other laboratory parameters were measured on admission before pPCI. Conclusions:Monocyte count on admission and low haemoglobin concentration were independent clinical predictors of no-reflow following pPCI in patients with STEMI. Our findings suggest that admission monocyte count may be available for early risk stratification of no-reflow after pPCI and might allow the improvement of strategies to prevent this phenomenon.

The Value of Pre-Infarction Angina and Plasma D-Dimer in Predicting No-Reflow After Primary Percutaneous Coronary Intervention in ST-Segment Elevation Acute Myocardial Infarction Patients

“…In addition, the no-reflow phenomenon is associated with poor long-term prognosis due to post-procedural myocardial infarction [ 8 ]. Although some potential predictors of no-reflow phenomenon have been reported, such as the platelet/lymphocyte ratio and monocyte count [ 9 , 10 ], more predictors are still urgently needed.…”

The relationship between serum rheumatoid factor level and no‐reflow phenomenon in patients with acute ST‐segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

“…Çelik et al recently demonstrated that female gender, pain to balloon time, high TIMI thrombus grade, tirofiban administration, mean platelet volume, and platelet‐lymphocyte ratio are independent predictors of no‐reflow after primary PCI in young patients. In addition, Wang et al revealed that monocyte count on admission and low hemoglobin concentration are independent clinical predictors of no‐reflow following primary PCI in patients with STEMI. Şahin et al reported that age, DM, acute anterior STEMI, the involvement of left main coronary artery or left anterior descending artery, and thrombus grade are independently associated with no‐reflow in the same population.…”

Association of Monocyte Count on Admission with the Angiographic Thrombus Burden in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

“…In all patients, blood samples for measurements were performed according to our previous work. 3 White blood cell (WBC) count, monocyte count, and other biochemical parameters were drawn into standard ethylenediaminetetraacetic acid (EDTA) containing tubes on admission in the emergency room before the administration of aspirin and clopidogrel. Common blood counting (CBC) parameters were measured by an automated blood cell counter (XS-1000i; Sysmex Co.).…”

“…In our previous reports, monocyte counts on admission independently predict no-reflow following primary PPCI. 3 In the current study, we aimed to investigate further the relationship between on admission monocyte count and angiographic intracoronary thrombus burden in patients receiving PPCI.…”