A short and facile synthesis of pyrido[2,3-d]pyrimidine derivatives was accomplished in good yields via the three-component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzylammonium chloride (TEBAC). The structures of these compounds were characterized by elemental analysis, IR and 1 H NMR spectra and further confirmed by single crystal X-ray diffraction analysis.
A series of pyrimido[4,5‐b]quinoline derivatives was synthesized by three‐component reaction of 6‐aminopyrimidine, aromatic aldehydes and 1,3‐cyclohexanedione or 5,5‐dimethyl‐1,3‐cyclohexanedione in aqueous media in the presence of triethylbenzylammonium chloride. This protocol has the advantages of higher yields, lower lost, easy work‐up, and environmentally friendly procedure. J. Heterocyclic Chem., 46, 237 (2009).
A series of pyrimido [4,5-b]quinoline derivatives was synthesized by three-component reaction of 6-aminopyrimidine, aromatic aldehydes and 1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione in aqueous media in the presence of triethylbenzylammonium chloride. This protocol has the advantages of higher yields, lower lost, easy work-up, and environmentally friendly procedure.
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