Three‐Component One‐Pot Synthesis of 1,4‐Dihydropyrano[2,3‐c]pyrazole Derivatives in Aqueous Media.

Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPARγ partial agonists

“…2.8.32 6-Amino-4-(2,4-dichlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (10ag) [ 32 ]. The title compound was synthesized from 2,4-dichlorobenzaldehyde (0.243 g) and 3-methyl-1-phenyl-1 H -pyrazol-5(4 H )-one (0.242 g) according to the general procedure.…”

Design, Characterization and Application of The SCMNPs@PC/VB1-Zn as A Green and Recyclable Biocatalyst for Synthesis of Pyrano[2,3-c]pyrazole and 4H-benzo-[b]-pyran Derivatives

“…Fe3O4 MNPs are particularly promi-tivities, including the inhibitors of human Chk1 kinase [22], antimicrobial [23], antiinflammatory [24], and anticancer [25] activities. In one of the important ways, pyrano [2,3c]pyrazole derivatives were synthesized by the three-component condensation reaction of pyrazolone, malononitrile, and aldehyde in the presence of various catalysts, such as: KF.2H2O [26], BF3/MNPs [27], p-dodecylbenzene sulfonic acid (DBSA) [28], H14[NaP5W30O110] [29], triethylbenzylammonium chloride (TEBA) [30], MgO [31], and hexadecyltrimethylammonium bromide (HTMAB) [32]. Most of the procedures reported for the preparation of these kind of heterocyclic compounds are associated with demerits such as long reaction time, low yields, the use of hazardous organic solvents, lack of general applicability, tedious work-up methods, use of toxic catalysts, and harsh reaction conditions.…”

H6P2W18O62·18H2O: A green and reusable catalyst for one-pot synthesis of pyrano[4,3-b]pyrans in water

“…Recently, a one-pot, threecomponent reaction of 4-hydroxy-6-methylpyran-2-one with malononitrile and aromatic aldehydes has enjoyed wider utilization in the synthesis of these compounds. A variety of reagents, such as piperidine [21,22], triethylbenzyl ammonium chloride [23], KF/Al 2 O 3 [24], magnesium oxide [25], ionic liquids [16,26], DBU [27], and also without any catalyst [28] have been employed to accomplish this transformation. Some of the reported methods suffer from serious limitations, such as long reaction times, complex synthetic pathways, tedious work-up, use of organic solvents, lower product yields and non-reusability of the catalyst.…”