A novel MOFs-303-functionalized magnetic probe with strong hydrophilicity was synthesized for the highly efficient analysis of N-linked glycopeptides and the discovery of potential biomarkers with hepatocellular carcinoma.
Efficient isolation and downstream bioinformation analysis of circulating tumor cells (CTCs) in whole blood contribute to the early diagnosis of cancer and investigation of cancer metastasis. However, the separation and release of CTCs remain a great challenge due to the extreme rarity of CTCs and severe interference from other cells in complex clinical samples. Herein, we developed a low-cost and easy-to-fabricate aptamer-functionalized wafer with a three-dimensional (3D) interconnected porous structure by grafting polydopamine (PDA), poly(ethylene glycol
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