Photoacoustic spectroscopy has been proved to be a potential method for noninvasive blood glucose detection. We used 1535 nm pulsed laser to excite photoacoustic signal in glucose solution and then explored the influence of different glucose concentration on photoacoustic signal to analyze the sensitivity of photoacoustic signal to glucose at this wavelength. We designed a simple photoacoustic cell structure, which used a focused ultrasonic transducer to receive signals, so as to reduce signal attenuation. In terms of the results, we have found that for high-concentration glucose solutions, the results have strong linearity and discrimination, and when the concentration is close to the human body level, the signal difference is not so obvious. Therefore, we explore the external factors affecting the photoacoustic signal in detail and propose a calibration method. Through calibration, the signal generated by the low-concentration glucose solution also has a good linearity.
Non-invasive, portable, economical, dynamic blood glucose monitoring device has become a functional requirement for diabetes in his regulating entire life. In a photoacoustic (PA) multispectral near-infrared diagnosis system, the glucose in aqueous solutions was excited by low power (order of milliwatts) CW laser whose wavelengths were from 1500 to 1630 nm. The glucose in aqueous solutions to be analyzed was contained within the photoacoustic cell (PAC). The PA multispectral signals were measured using a piezoelectric detector, and then the voltage signals from the piezoelectric detector were amplified with a precision Lock-in Amplifier (MFLI500K). The continuously tunable lasers were used to verify the various influencing factors of the PA signal, and the PA spectrum of the glucose solution was examined. Subsequently, six wavelengths with high power were selected at approximately equal intervals from 1500 to 1630 nm, and the gaussian process regression of the quadratic rational kernel was used to collect data through these wavelengths to predict the glucose concentration. The experimental results showed that the near-infrared PA multispectral diagnosis system could be engineered for the prediction of the glucose level (more than 92%, zone A of Clarke Error Grid). Subsequently, the model trained with glucose solution was used to predict serum glucose. With the increase of serum glucose content, the prediction results of the model also showed a high linear relationship, indicating that the photoacoustic method was sensitive to the detection of glucose concentration changes. The results of our study have the potential to not only better develop the PA blood glucose meter but also extend the viability into the detection of otherwise blood components.
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