Scope
Published data support that fish oil and algae oil rich in ω‐3 polyunsaturated fatty acids (PUFAs) protect against hyperlipidemia in mice. This study is aimed to explore the effects of fish oil and algae oil on high‐fat diet (HFD) induced circadian intestinal microbes dysregulation.
Methods and Results
Male C57BL/6 mice are randomly divided into four groups, which are fed a normal chow diet (CON), a HFD, a HFD supplemented with fish oil (FO), and a HFD supplemented with algae oil (AO), respectively, for 12 weeks. At the end of the experiment, mice are sacrificed at 12 h intervals with the first one at zeitgeber time 0 (ZT0) and the second at zeitgeber time 12 (ZT12). FO and AO groups ameliorate diet‐induced hyperlipidemia. The relative abundance of certain genera is improved in FO and AO groups according to 16S rRNA gene sequencing. The short‐chain fatty acids (SCFAs) producing bacteria Butyricimonas and some of the genera in the Lachnospiraceae recover to the normal circadian rhythm in both FO and AO groups.
Conclusion
The data show that FO and AO alleviate circadian gut microbiota dysregulation in mice caused by HFD, and support the further investigation of ω‐3 PUFAs as a dietary intervention strategy for the prevention of hyperlipidemia.
Mol. Nutr. Food Res. 2019, 63, 1900492
DOI: https://doi.org/10.1002/mnfr.201900492
Circadian clocks control biological activities and nutrient metabolism, but little is known about the impact of intestinal flora. In article number 1900492, Zhiguo Liu and co‐workers observe the disturbance of the circadian rhythm of intestinal flora under a high‐fat diet and the significant improvement of intestinal flora by adding fish oil or algae oil, which supported ω‐3 PUFA as an intervention strategy for metabolic‐related intestinal flora balance regulation.
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