Cancer possesses normoxic and hypoxia microenvironments with different levels of oxygen, needing different efficacies of photothermal and photodynamic therapies. It is important to precisely tune the photothermal and photodynamic effects of phototherapy nano‐agents for efficient cancer treatment. Now, a series of copolymeric nanoparticles (PPy‐Te NPs) were synthesized in situ by controlled oxidative copolymerization with different ratios of pyrrole to tellurophene by FeCl3. The photothermal and photodynamic effects of semiconducting nano‐agents under the first near‐infrared (NIR) irradiation were precisely and systematically tuned upon simply varying the molar ratio of the pyrrole to tellurophene. The PPy‐Te NPs were used for cancer treatment in mice, exhibiting excellent biocompatibility and therapeutic effect. This work presents a simple method to tune photothermal and photodynamic therapies effect in semiconducting nano‐agents for cancer treatment.
Semiconducting
polymer (SP) nanoparticles (NPs) have recently emerged
as one of the most promising agents for photoacoustic imaging (PAI)-guided
photothermal/photodynamic therapy (PTT/PDT). Herein, a triplet tellurophene-based
SP (PNDI-2T) was synthesized with efficient tin-free direct heteroarylation
polycondensation. The PNDI-2T NPs display remarkable near-infrared
absorption and low cytotoxicity. In addition, PNDI-2T NPs can generate
abundant reactive oxygen species (ROS) since tellurophene facilitates
the intersystem crossing to generate triplet excited states. Remarkably,
PNDI-2T NPs present a high photothermal conversion efficiency (η
= 45%) and a high ROS yield (ΦΔ = 38.7%) under 808 nm
laser irradiation. Furthermore, we showed that PNDI-2T NPs could be
excellent PAI-guided PTT/PDT agents for cancer theranostics. This
study provides a new route to developing highly efficient and low
cytotoxic agents for PAI-guided PTT/PDT.
Uniform MoO3 nanobelts and nanomaterials with various morphology are successfully synthesized via a facile hydrothermal method with nitric acid as additive. The obtained MoO3 nanomaterials were characterized by means of XRD, SEM, SAED and TEM. In addition, the
photocatalytic property of MoO3 nanomaterials have been studied, showing the excellent photocatalytic property for degradation of rhodamine-B (RhB) under simulated sunlight irradiation (visible light).
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