ESPR f all children with febrile seizures (FS) 15 to 8doA are reported to have recurrent S. Children at increased risk of frequent recurrences might be candidates for some orm of proph lactic treatment. Accurate assessment of the individual child's ecurrence risi is therefore essential. To determine Me risk of subsequent seizures fter a 1st. 2nd or 3rd e isode of,FS we used the findings of our large collaborative ohort stud (J Pediatr f994, April issue). ata on 24&6 children with a total number of 3459 episodes at risk for a subse uent S until the age of 5 ears were examined. The overall recurrence rate after .?st, a nd or 3rd FS was 3&, 47% and 43% respective1 A chi!d's attained age was the 1 ost im~ortant determinant of seizure recurrence. 8ther sionificant factors were a prognostic index identifieschildren at high~ahd lowrkk for and can be a usefui tool for clin~cal practice. THE EFFECT OF PHYSIOLOGICAL VARIABLES ON MEAN PEAK CEREBRAL BLOOD FLOW VELOCITY (MV) IN PRETERM VENTILATED NEONATES.Arne Ohlsson. Katherine Fong. Mary Lou Ryan. Laurel Yap. T e r r i L .Myhr. Departments of Newborn and Developmental P a e d i a t r i c s and Diagnostic Imaging. and Perinatal C l i n i c a l Epidemiology Unit. U n i v e r s i t y o f Toronto. Toronto. O n t a r i o . Canada O b j e c t i v e : To study i n v e n t i l a t e d neonates t h e e f f e c t of p h y s i o l o g i c a l v a r i a b l e s on MV i n t h e i n t e r n a l c a r o t i d (ICA). t h e a n t e r i o r c e r e b r a l (ACA). and t h e middle c e r e b r a l a r t e r i e s (MCA) Materiallmethods:65 q u i e t . s t a b l e . v e n t i l a t e d neonates ( g e s t a t i o n a l age 24-32 weeks) with no echocardiographic evidence o f a p a t e n t d u c t u s a r t e r i o s u s (PDA) were s t u d i e d on 106 o c c a s i o n s . u s i n g Doppler technique ( P e d i a t r Radio1 1991:21.395). Stepwise r e g r e s s i o n a n a l y s i s was used t o a s s e s s t h e e f f e c t o f physiological v a r i a b l e s on MV. R e s u l t s : Easel i n e c h a r a c t e r i s t i c s : weight (W) 613-1830 g . age 0.29-33 days, haematocrit (Hct) 0 . 2 9 -0 . 5 8 . mean a r t e r i a l blood pressure (MBP) 20-66 mm Hg. v e n t i l a t i o n index (VI ) (peak i n s p i r a t o r y pressure x vent1 l a t o r y r a t e ) 60-1560, pH 7 . 2 7 -7 . 5 6 . apCO, 24-65 rnmHg. apO 31 109 mmHg Welght. Hct. MBP, and VI were t h e most important varia$les i n t h e r e g r e s s i o n model i n a l l v e s s e l s . The r e g r e s s i o n equation f o r MV i n t h e r i g h t ICA i s given a s an example Log(MV)=2 69+0 00046(W)+O.O093(MBP)-1 6 6 ( H c t ) -0.00039(VI) Conclusions: P h y s~o l o g i c a l v a r i a b l e s influenced MV i n t h e major i n t r a c r a n i a l v e s s e l s in t h e s e s t a b l e , vent1 l a t e d . preterm neonates w i t h o u t a PDA A PROSPECTIVE STUDY COMPARING SYSTEUATIC INTERVIEW & ANALYSIS OF MATERNAL HAIR AND MECONIUM TO DETERMINE ILLICIT DRUG USE DURING PREGNANCY. Enrique Ostrea, J r . , Kirk Knapp, Anthony Oatrea, Libby Tannenbaum...
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