We propose pilot reuse (PR) in single cell for massive multiuser multiple-input multiple-output (MIMO) transmission to reduce the pilot overhead. For spatially correlated Rayleigh fading channels, we establish a relationship between channel spatial correlations and channel power angle spectrum when the base station antenna number tends to infinity. With this channel model, we show that sum mean square error (MSE) of channel estimation can be minimized provided that channel angle of arrival intervals of the user terminals reusing the pilots are non-overlapping, which shows feasibility of PR over spatially correlated massive MIMO channels with constrained channel angular spreads. Regarding that channel estimation performance might degrade due to PR, we also develop the closed-form robust multiuser uplink receiver and downlink precoder that minimize sum MSE of signal detection, and reveal a duality between them. Subsequently, we investigate pilot scheduling, which determines the PR pattern, under two minimum MSE related criteria, and propose a low complexity pilot scheduling algorithm which relies on the channel statistics only. Simulation results show that the proposed PR scheme provides significant performance gains over the conventional orthogonal training scheme in terms of net spectral efficiency.

SUMMARY Regulation of RNA degradation plays an important role in the control of gene expression. One mechanism of eukaryotic mRNA decay proceeds through an initial deadenylation followed by 5′-end decapping and exonucleolytic decay. Dcp2 is currently believed to be the only cytoplasmic decapping enzyme responsible for decapping of all mRNAs. Here we report that Dcp2 protein modestly contributes to bulk mRNA decay and surprisingly is not detectable in a subset of mouse and human tissues. Consistent with these findings, a hypomorphic knockout of Dcp2 had no adverse consequences in mice. In contrast, the previously reported Xenopus nucleolar decapping enzyme, Nudt16, is an ubiquitous cytoplasmic decapping enzyme in mammalian cells. Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis, Angiomotin-like 2. These data demonstrate mammalian cells possess multiple mRNA decapping enzymes, including Nudt16 to regulate mRNA turnover.

Low earth orbit (LEO) satellite communications are expected to be incorporated in future wireless networks, in particular 5G and beyond networks, to provide global wireless access with enhanced data rates. Massive multiple-input multiple-output (MIMO) techniques, though widely used in terrestrial communication systems, have not been applied to LEO satellite communication systems. In this paper, we propose a massive MIMO transmission scheme with full frequency reuse (FFR) for LEO satellite communication systems and exploit statistical channel state information (sCSI) to address the difficulty of obtaining instantaneous CSI (iCSI) at the transmitter. We first establish the massive MIMO channel model for LEO satellite communications and simplify the transmission designs via performing Doppler and delay compensations at user terminals (UTs). Then, we develop the low-complexity sCSI based downlink (DL) precoder and uplink (UL) receiver in closed-form, aiming to maximize the average signal-to-leakageplus-noise ratio (ASLNR) and the average signal-to-interferenceplus-noise ratio (ASINR), respectively. It is shown that the DL ASLNRs and UL ASINRs of all UTs reach their upper bounds under some channel condition. Motivated by this, we propose a space angle based user grouping (SAUG) algorithm to schedule the served UTs into different groups, where each group of UTs use the same time and frequency resource. The proposed algorithm is asymptotically optimal in the sense that the lower

Abstract-We propose adjustable phase shift pilots (APSPs) for channel acquisition in wideband massive multiple-input multipleoutput (MIMO) systems employing orthogonal frequency division multiplexing (OFDM) to reduce the pilot overhead. Based on a physically motivated channel model, we first establish a relationship between channel space-frequency correlations and the channel power angle-delay spectrum in the massive antenna array regime, which reveals the channel sparsity in massive MIMO-OFDM. With this channel model, we then investigate channel acquisition, including channel estimation and channel prediction, for massive MIMO-OFDM with APSPs. We show that channel acquisition performance in terms of sum mean square error can be minimized if the user terminals' channel power distributions in the angle-delay domain can be made nonoverlapping with proper phase shift scheduling. A simplified pilot phase shift scheduling algorithm is developed based on this optimal channel acquisition condition. The performance of APSPs is investigated for both one symbol and multiple symbol data models. Simulations demonstrate that the proposed APSP approach can provide substantial performance gains in terms of achievable spectral efficiency over the conventional phase shift orthogonal pilot approach in typical mobility scenarios.

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Determining the monoisotopic peak of a precursor is a first step in interpreting mass spectra, which is basic but non-trivial. The reason is that in the isolation window of a precursor, other peaks interfere with the determination of the monoisotopic peak, leading to wrong mass-to-charge ratio or charge state. Here we propose a method, named pParse, to export the most probable monoisotopic peaks for precursors, including co-eluted precursors. We use the relationship between the position of the highest peak and the mass of the first peak to detect candidate clusters. Then, we extract three features to sort the candidate clusters: (i) the sum of the intensity, (ii) the similarity of the experimental and the theoretical isotopic distribution, and (iii) the similarity of elution profiles. We showed that the recall of pParse, MaxQuant, and BioWorks was 98-98.8%, 0.5-17%, and 1.8-36.5% at the same precision, respectively. About 50% of tandem mass spectra are triggered by multiple precursors which are difficult to identify. Then we design a new scoring function to identify the co-eluted precursors. About 26% of all identified peptides were exclusively from co-eluted peptides. Therefore, accurately determining monoisotopic peaks, including co-eluted precursors, can greatly increase peptide identification rate.