Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

Zhao, Yang; Sun, Rui; You, Li; Chunyi, Gao; Tian, Zhigang

doi:10.1016/s0006-291x(02)02838-3

Cited by 193 publications

(146 citation statements)

References 29 publications

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“…Since there is evidence that leptin deficiency reduces IL-15 expression in hepatic Kupffer cells and leads to NK cell depletion in ob/ob livers (24), further studies are warranted to examine whether db/db BM produces reduced level of IL-15 that contributes to impaired NK cell development. Nevertheless, our current data suggest that the previously observed NK cell reduction in the spleen of db/db mice might be possibly attributed at least in part to the impaired NK cell development in BM rather than selective reduction of mature splenic NK cells in the peripheral lymphoid system (13).…”

Section: Discussionmentioning

confidence: 47%

“…Recently, we have demonstrated an essential role for leptin signaling in the survival and maturation of BM-derived DCs, along with induction of CD40 expression via the activation of Akt (11,12). Previous studies by Zhao et al have revealed that NK cells express the leptin receptor (13). In addition, reduced numbers of NK cells in various peripheral organs such as spleen and liver have been observed in db/db mice, but it remains unclear whether impaired leptin signaling affects NK cell development in the BM (14).…”

Section: Introductionmentioning

confidence: 90%

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Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

Lam

Yang

et al. 2009

Cell Mol Immunol

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Increasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). In this study, we have characterized NK cell differentiation and maturation in the BM of leptin-receptor deficient db/db mice at a prediabetic stage. Although the BM cellularity was similar to the control value, the total number of NK cells was severely reduced in mutant mice.

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Section: Discussionmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 90%

Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

Lam

Yang

et al. 2009

Cell Mol Immunol

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“…Besides its potent effects on basophils, leptin shows pleiotropic effects on various types of inflammation, including Th2-mediated reactions. Leptin promotes proliferation of human monocytes (54) and NK cells (55) and their production of inflammatory cytokines protects neutrophils and eosinophils from apoptosis (23,24) and promotes T cell activation (39). Also, leptin is reported to negatively modulate regulatory T cell proliferation and function (56,57), which may lead to increased severity of inflammation due to decreased immunological tolerance.…”

Section: Discussionmentioning

confidence: 99%

Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of Human Basophils

Suzukawa

Nagase

Ogahara

et al. 2011

The Journal of Immunology

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Basophils are the rarest leukocytes in human blood, but they are now recognized as one of the most important immunomodulatory as well as effector cells in allergic inflammation. Leptin, a member of the IL-6 cytokine family, has metabolic effects as an adipokine, and it is also known to participate in the pathogenesis of inflammatory reactions. Because there is an epidemiologic relationship between obesity and allergy, we examined whether basophil functions are modified by leptin. We found that human basophils express leptin receptor (LepR) at both the mRNA and surface protein levels, which were upregulated by IL-33. Leptin exerted strong effects on multiple basophil functions. It induced a strong migratory response in human basophils, similar in potency to that of basophil-active chemokines. Also, leptin enhanced survival of human basophils, although its potency was less than that of IL-3. Additionally, CD63, a basophil activation marker expressed on the cell surface, was upregulated by leptin, an effect that was neutralized by blocking of LepR. Assessments of basophil degranulation and cytokine synthesis found that leptin showed a strong priming effect on human basophil degranulation in response to FcεRI aggregation and induced Th2, but not Th1, cytokine production by the cells. In summary, the present findings indicate that leptin may be a key molecule mediating the effects of adipocytes on inflammatory cells such as basophils by binding to LepR and activating the cellular functions, presumably exacerbating allergic inflammation.

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“…All isoforms share an identical extracellular ligand-binding domain (12). Leptin's functional receptor (ObRb) is expressed not only in the hypothalamus where it regulates energy homeostasis and neuroendocrine function, but also in all cell types of innate and adaptive immunity (13)(14)(15)(16). The full-length b isoform (ObR b ) lacks intrinsic tyrosine kinase activity, is involved in several downstream signal transduction pathways, and has been identified in immune cells of both animals and humans (13) (Fig.…”

Section: Leptin and Leptin Signaling In Immune Cellsmentioning

confidence: 99%

Leptin in Immunology

Matarese

Moschos

Mantzoros

2005

The Journal of Immunology

508

426

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Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.

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Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

Cited by 193 publications

References 29 publications

Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of Human Basophils

Leptin in Immunology

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