To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, Pmeta = 2.48 × 10−10, odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, Pmeta = 2.72 × 10−17, OR = 1.49. The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (Ptrend = 0.0008 and 0.0002, respectively). We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10−14).

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Authorship identity has long been an Achilles' heel in bibliometric analyses at the individual level. This problem appears in studies of scientists' productivity, inventor mobility and scientific collaboration. Using the concepts of cognitive maps from psychology and approximate structural equivalence from network analysis, we develop a novel algorithm for name disambiguation based on knowledge homogeneity scores. We test it on two cases, and the results show that this approach outperforms other common authorship identification methods with the ASE method providing a relatively simple algorithm that yields higher levels of accuracy with reasonable time demands.

This paper examines the rapid growth of China in the field of nanotechnology and the rise of collaboration between China and the US in this emerging domain. Chinese scientific papers in nanotechnology are analyzed to indicate overall trends, leading fields and the most prolific institutions. Patterns of China-US nanotechnology paper coauthorship are examined over the period 1990-2009, with an analysis of how these patterns have changed over time. The paper combines bibliometric analysis and science mapping. We find rapid development in the number of China-US co-authored nanotechnology papers as well as structural changes in array of collaborative nanotechnology sub-fields. Implications for both China and the US of this evolving relationship are discussed.