INTRODUCTION-99m Tc-rBitistatin is a radioligand for the αIIbβ3 (GPIIb/IIIa) receptor on platelets and is being developed as a diagnostic radiopharmaceutical for in vivo imaging of acute thrombi and emboli. Prior to the first administration of 99m Tc-rBitistatin to human subjects, its biodistribution and effects on platelets were evaluated in animals. This paper reports the findings of the animal studies in comparison with the initial findings in normal human subjects.
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