Endoscopic pyloric suturing to facilitate weight loss: a canine model

Vegesna, Anil K.; Korimilli, Annapurna; Besetty, Ramaseshai; Bright, Lewis; April, Milton; Agelan, Alexis; McIntyre, K.; Malik, Aslam; Miller, Larry S.

doi:10.1016/j.gie.2010.03.1071

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…Using breaking force, we systematically described a small proportion of the tissue properties of fresh porcine intestinal segments and were able to describe relationships between the intestinal segments similar to those described in humans, although using a different method [11]. Our results differed from those in dogs [57], which is relevant as dogs had been and still are relevant animal models of interventions [73][74][75]. The differing results, compared to Christensen et al [72], might be attributed to the method or the freeze-thawing used in their work.…”

Section: Discussionmentioning

confidence: 86%

Not All Porcine Intestinal Segments Are Equal in Terms of Breaking Force, but None Were Associated to Allometric Parameters

Kratz,

Dauvergne,

Kronberg

et al. 2023

Gastroenterology Insights

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Biomechanics are gaining ground in gastroenterology in the creation of educational models and to describe the necessary forces to perforate hallow organs during endoscopy. We thus investigated the breaking forces of porcine intestinal segments and whether they could be predicted based on body weight or crown–rump length. Based on a priori power-analyses, 10 pigs were included. The breaking forces were determined with a motorized test stand. We found that the breaking forces of intestinal segments were different (H(6) = 33.7, p < 0.0001): Ileal breaking force (x¯ = 24.14 N) was higher than jejunal (x¯ = 14.24 N, p = 0.0082) and colonic (x¯ = 11.33 N, p < 0.0001) breaking force. The latter was also smaller than cecal breaking force (x¯ = 24.6 N, p = 0.0044). Likewise, rectal (x¯ = 23.57 N) breaking force was higher than jejunal (p = 0.0455) and colonic (p = 0.0006) breaking force. Breaking forces were not correlated to body weight or crown–rump length (R < 0.49, p > 0.148). Intestinal segments differ in their breaking forces. The colon had the least resistance to traction forces. It remains to be determined if similar relationships exist in humans in order to validate porcine models for endoscopy and surgery.

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Section: Discussionmentioning

confidence: 86%

Not All Porcine Intestinal Segments Are Equal in Terms of Breaking Force, but None Were Associated to Allometric Parameters

Kratz,

Dauvergne,

Kronberg

et al. 2023

Gastroenterology Insights

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show abstract

“…Further studies are required to quantify the type of weight loss that could be effected using this type of “neuromodulation.” Pyloric suturing has also been used in canine models to induce a delayed gastric emptying state. xlii While weight loss was shown in dogs that underwent pyloric suturing, long-term feasibility of this strategy remains to be determined.…”

Section: Future Directionsmentioning

confidence: 99%

Current Status of Endoluminal Bariatric Procedures for Primary and Revision Indications

Ryou

Ryan

Thompson

2011

Gastrointestinal Endoscopy Clinics of North America

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“…18,19 Several suture systems have been proposed for the successful closure of the gastric wall after NOTES, including T-tags, clip-G Padlock, and the OVESCO system. [20][21][22][23][24][25] The aim of this experimental study was to demonstrate the feasibility and reproducibility of a simple gastrojejunal anastomosis procedure in a living porcine model exclusively using NOTES.…”

Section: Introductionmentioning

confidence: 99%