Gastric ulcer is an injury that develops on the lining of the stomach due to an imbalance between aggressive and defensive agents. Chitosan derivatives demonstrate promising biological activities in accelerating the healing activity of gastric lesions. Thus, this study aimed at investigating the healing activity of gastric lesion, induced by acetic acid (80%), of the chitosan derivative with acetylacetone (Cac) modified with ethylenediamine (Cacen) or diethylenetriamine (Cacdien). The biological activity was determined based on cytotoxicity, antibacterial activity, and gastroprotective activities. The results showed no significant difference in the cytotoxicity, a better antibacterial activity against S. aureus and E. coli, and a positive result on the healing of gastric lesions of the materials (Cac 18.4%, Cacen 55.2%, and Cacdien 68.1%) compared to pure chitosan (50.7%). Therefore, the results indicate that derivatives of chitosan are promising biomaterials for application in the control of lesions on the gastric mucosa.
A biodiversidade da flora, o funcionamento e a conservação dos ecossistemas de ambientes degradados podem ser entendidos através de informações geradas por pesquisas florísticas. Assim, objetivou-se realizar um inventário florístico de fanerógamas do Parque Ambiental do Brejo do Buritis em Gilbués, Piauí. Para tal, foi realizado o método de ponto quadrante com quatro parcelas de 10x10 m2, na região que abrange uma nascente hídrica próxima à zona urbana. O material coletado foi herborizado, identificado, classificado e as duplicatas foram direcionadas ao acervo do Herbário Graziela Barroso da Universidade Federal do Piauí (TEPB), para ratificação da classificação e registro. Concomitantemente, foram realizadas análise observacional e estudo bibliográfico para caracterização do ecossistema e identificação de fatores relacionados à vulnerabilidade ambiental. A região em estudo apresentou vegetação típica com mata ciliar e trechos de vereda, no entanto, é uma área poluída com lixo doméstico, construção de moradia irregular e desmatamento, que podem influenciar o assoreamento do brejo. Foram coletadas trinta espécies de fanerógamas distribuídas em vinte e três famílias, destas, 50% foram incluídas no herbário e estão disponíveis para estudantes e pesquisadores. As mais representativas em número de espécimes foram Piperaceae (17,7%), Poaceae (11,1%), Arecaceae (6,6%), Cucurbitaceae (6,6%) e Vitaceae (6,6%). Foram identificadas espécies com propriedades farmacológicas, econômicas, bioindicadores, ornamentais e de uso em recuperação de áreas degradadas. Esta pesquisa possibilitou o conhecimento de uma amostra da biodiversidade vegetal do Parque Ambiental do Brejo dos Buritis, primordial para estratégias de conservação dos ecossistemas e reflorestamento, ações preconizadas pelos Objetivos do Desenvolvimento Sustentável (ODS) da agenda 2030. Palavras-chave: Inventário Florístico. Degradação Ambiental. Unidade de Conservação. Abstract The biodiversity of flora, the functioning and conservation of ecosystems in degraded environments can be understood through information generated by floristic surveys. Thus, the objective was to carry out a floristic inventory of phanerogamous of Environmental Park Brejo dos Buritis in Gilbués, Piauí. Thus, the Quadrant Point method was performed with four 10x10 m2 plots, in the region that covers a water source near the urban area. The collected material was herborized, identified, classified and the duplicates were directed to the collection of Graziela Barroso Herbarium of the Federal University of Piauí (UFPI), for ratification of classification and registration. Concomitantly, observational analysis and bibliographic study were performed to characterize the ecosystem and identify factors related to environmental vulnerability. The region under study presented typical vegetation with riparian forest and stretches of path, however it is a polluted area with household waste, irregular housing construction and deforestation, which can influence the swamp siltation. Thirty species of phanerogams distributed in 23 families were collected, of which 50% were included in the herbarium and are available to students and researchers. The most representative in number of specimens were Piperaceae (17.7%), Poaceae (11.1%), Arecaceae (6.6%), Cucurbitaceae (6.6%) and Vitaceae (6.6%). Species with pharmacological, economic, bioindicator, ornamental and recovery use of degraded areas were identified. This research allowed the knowledge of a sample of the vegetal biodiversity of the Environmental Park Brejo dos Buritis, primordial for strategies of ecosystem conservation and reforestation, actions recommended by the 2030 Agenda Sustainable Development Goals (SDG). Keywords: Floristic Inventory. Ambiental Degradation. Conservation Unit.
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