Biological properties of chitosan derivatives associated with the ceftazidime drug

Pereira, Leudimar Aires; Reis, Luizângela da Silva; Batista, Felipe Alves; Mendes, Anderson Nogueira; Osajima, Josy Anteveli; Filho, Edson Cavalcanti da Silva

doi:10.1016/j.carbpol.2019.115002

Cited by 38 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitosan (CS), a cationic polysaccharide, is obtained from the N-deacetylation of chitin [ 14 ]. Due to its potential in immune modulation, antioxidant function, biocompatibility, and wide-spectrum antibacterial activity [ 15 ], chitosan has been widely applied in aquaculture [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chitosan–Gentamicin Conjugate Supplement on Non-Specific Immunity, Aquaculture Water, Intestinal Histology and Microbiota of Pacific White Shrimp (Litopenaeus vannamei)

Liang

Hou

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan–gentamicin conjugate (CS-GT) after Litopenaeus vannamei were infected with Vibrio parahaemolyticus, through nonspecific immunity parameter detection, intestinal morphology observation, and the assessment of microbial flora diversification by 16S rRNA gene sequencing. The results showed that the oral administration of CS-GT significantly increased total hemocyte counts and reduced hemocyte apoptosis in shrimp (p < 0.05). The parameters (including superoxide dismutase, glutathione peroxidase, glutathione, lysozyme, acid phosphatase, alkaline phosphatase, and phenoloxidase) were significantly increased (p < 0.05). The integrity of the intestinal epithelial cells and basement membrane were enhanced, which correspondingly alleviated intestinal injury. In terms of the microbiome, the abundances of Vibrio (Gram-negative bacteria and food-borne pathogens) in the water and gut were significantly reduced. The canonical correspondence analysis (CCA) showed that the abundances of Vibrio both in the water and gut were negatively correlated with CS-GT dosage. In conclusion, the oral administration of CS-GT can improve the immunity of shrimp against pathogenic bacteria and significantly reduce the relative abundances of Vibrio in aquaculture water and the gut of Litopenaeus vannamei.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Chitosan–Gentamicin Conjugate Supplement on Non-Specific Immunity, Aquaculture Water, Intestinal Histology and Microbiota of Pacific White Shrimp (Litopenaeus vannamei)

Liang

Hou

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Except for 1a and 1e, the hemolysis rates of all the test samples were lower than 5%. This was an acceptable value for biomaterial applications [34]. Regarding 1a and 1e, their hemolysis rates were slightly higher than 5% only when the concentration arrived at 1000 μg/mL.…”

Section: Hemolysis Assaymentioning

confidence: 81%

“…1 H NMR spectra in Figure 2 was applied to further confirm the structure of the derivatives. According to literature [34], the signals of starch backbone were located at 3.0-5.7 ppm. The signal of α-anomeric hydrogen (H1) of the native starch was at 5.1 ppm and six other AGU protons (H2-H6) were around 3.2-4.0 ppm [35].…”

Section: Structure Characterizationmentioning

confidence: 95%

See 1 more Smart Citation

Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives

et al. 2020

View full text Add to dashboard Cite

In this study, starch was chemically modified to improve its antioxidant activity. Five novel cationic 1,2,3-triazole functionalized starch derivatives were synthesized by using “click” reaction and N-alkylation. A convenient method for pre-azidation of starch was developed. The structures of the derivatives were analyzed using FTIR and 1H NMR. The radicals scavenging abilities of the derivatives against hydroxyl radicals, DPPH radicals, and superoxide radicals were tested in vitro in order to evaluate their antioxidant activity. Results revealed that all the cationic starch derivatives (2a–2e), as well as the precursor starch derivatives (1a–1e), had significantly improved antioxidant activity compared to native starch. In particular, the scavenging ability of the derivatives against superoxide radicals was extremely strong. The improved antioxidant activity benefited from the enhanced solubility and the added positive charges. The biocompatibility of the cationic derivatives was confirmed by the low hemolytic rate (<2%). The obtained derivatives in this study have great potential as antioxidant materials that can be applied in the fields of food and biomedicine.

show abstract

“…Chitosan is a natural mucoadhesive polymer, which can directly attach to the GI surface and increase cellular uptake at the target site [18,24,25]. Chitosan increases quinone reductase (QR) and glutathione S-transferases (GST) activities, and glutathione (GSH) concentration by deterrent ornithine decarboxylase (ODC) activity and cyclooxygenase-2 (COX-2) expression which causing chemo-preventive activity against colon cancer [26].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation

Sharifi

Jahangiri

Ebrahimnejad

2021

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

show abstract

Biological properties of chitosan derivatives associated with the ceftazidime drug

Cited by 38 publications

References 35 publications

Effects of Chitosan–Gentamicin Conjugate Supplement on Non-Specific Immunity, Aquaculture Water, Intestinal Histology and Microbiota of Pacific White Shrimp (Litopenaeus vannamei)

Effects of Chitosan–Gentamicin Conjugate Supplement on Non-Specific Immunity, Aquaculture Water, Intestinal Histology and Microbiota of Pacific White Shrimp (Litopenaeus vannamei)

Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation

Contact Info

Product

Resources

About