Objective:The aim of the present study was to evaluate the synergistic anti-inflammatory effect of Non-steroidal anti-inflammatory drugs (NSAIDs) plus B vitamins administered pre and postoperatively in surgeries of impacted mandibular third molars. Material and Methods: Double-blind randomized clinical trial, sixty-six patients participated and were randomized into 2 groups. The control group was administered meloxicam 15 mg intramuscularly plus placebo orally and to the experimental group, meloxicam 15 mg intramuscularly plus vitamins B [B1, B6, and B12] orally; both treatments were administered preoperatively. The anti-inflammatory effect was evaluated by pain intensity, facial swelling (facial contour measurements), and mouth opening (distance between the upper and lower incisors) during the post-surgical phase. Student's t-test was performed for independent samples. Results: In all the evaluated times (1 hour, 6 hours, 12 hours, 24 hours, 2 days, and 3 days after the end of the surgery) the experimental group presented a significantly lower intensity of pain compared to the control group (p<0.05). The highest pain intensity was recorded at 6 hours (17.7 ± 9.1 mm in the experimental group and 34.5 ± 21.3 mm in the control group). Swelling and mouth opening were similar in both groups, at all times evaluated (p>0.05). Conclusion: In the present study, the administration of NSAIDs plus B vitamins (B1, B6, B12) produced lower intensity of pain compared to the administration of only NSAIDs. Nevertheless, swelling and mouth opening were similar in all evaluations for both study groups.

Background: The anterior loop is the extension of the inferior dental nerve which is one of the most important anatomical landmarks to consider when placing dental implants or any other surgical procedure that involves the chin region. Determining the frequency and characteristics of the anterior loop is important to reduce the risk of complications in the chin region as a result of the implant or regenerative surgeries. For this reason, the objective of the study was to determine the prevalence and characteristics of the anterior loop in adult patients using Cone Beam computed tomography. Methods: A Cross-sectional study of 93 Cone Beam computed topographies (CBCT) obtained from patients of the Faculty of Dentistry of the UNMSM during the period 2016-2017. CBCTs were analyzed and measurements of the anterior projection (AP) and caudal projection (CP) of the anterior loop were performed. In addition, the distance of the anterior loop to the alveolar ridge (D-AR) and the buccal table (D-BP) was evaluated. Results: The prevalence of the anterior loop was 95.1% (n=177) and with an average AP of 2.67 ± 1.36 mm. In AP and CP, a significant difference was evidenced concerning dental status on the right side (p <0.05). The CP of the anterior loop was 5.27 ± 1.69 mm; the rods presented a higher value on the side with 5.94 ± 2.01 mm (p = 0.01); the completely edentulous patients presented a higher value on the side with 7.00 ± 1.13 mm (p = 0.036). The D-AR was 15.33 ± 2.45 mm and the D-BP was 4.97 ± 1.40 mm. Conclusions: In this study, it was found that there is a high prevalence of the anterior loop (95.1%) with an average length of 2.67 mm. In addition, some characteristics associated with the anterior loop were found, such as its anterior projection with dental status and its caudal projection with gender and dental status.