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Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg(-1), showing potential as an anti-Alzheimer's drug.

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in the theoretical study of the coordination of three ligands derived from 8-hydroxyquinoline (8-HQ) with N-acylhydrazone: 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone (INHHQ), 2-[(8-hydroxyquinolinyl)methylene] acetohydrazide (8-H 2 QH) and 2-[(8-hydroxyquinolinyl)methylene] hydrazinecarboxamide (8-H 2 QS); with the Zn 2+ ion. These complexes prevent interactions of the metal ions present in the brain, with the β-amyloid peptide (Aβ), avoiding the formation of aggregates that are responsible for the development of the Alzheimer's disease. The results show that the three ligands coordinate the Zn 2+ ion in a tridentate form through the O and N atoms of the 8-hydroxyquinoline center and the N of the hydrazonic group, completing the coordination sphere with two chloride ions, creating a bipyramidal structure trigonal, different from the structures of the complexes reported in the literature.

Readers of Joyce know the character Gabriel Conroy from Dubliners’ final, longest, and most famous short story, “The Dead”. But the question whether they have read a novel called Gabriel Conroy will certainly make most of those readers frown. Yet before the protagonist of “The Dead” was created by Joyce, another character in literature had been called by this name, Captain Gabriel Conroy, from Bret Harte’s 1876 homonymous novel. By choosing that name for the protagonist of his short story, Joyce established a dialogue, although a possibly superficial one, between his work and that of Harte.