Estudo Teórico De Potenciais Agentes Para O Tratamento Da Doença De Alzheimer Derivados Da 8-Hidroxiquinolina Com Substituintes Do Tipo N-Acil-Hidrazona

Abstract

in the theoretical study of the coordination of three ligands derived from 8-hydroxyquinoline (8-HQ) with N-acylhydrazone: 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone (INHHQ), 2-[(8-hydroxyquinolinyl)methylene] acetohydrazide (8-H 2 QH) and 2-[(8-hydroxyquinolinyl)methylene] hydrazinecarboxamide (8-H 2 QS); with the Zn 2+ ion. These complexes prevent interactions of the metal ions present in the brain, with the β-amyloid peptide (Aβ), avoiding the formation of aggregates that are responsible for the development of the Alzheimer's disease. The results show that the three ligands coordinate the Zn 2+ ion in a tridentate form through the O and N atoms of the 8-hydroxyquinoline center and the N of the hydrazonic group, completing the coordination sphere with two chloride ions, creating a bipyramidal structure trigonal, different from the structures of the complexes reported in the literature.

Care Strategies for the Elderly with Alzheimer's Disease: Integrative Literature Review

“…In this context, Alzheimer's disease (AD) emerges, which is characterized as a neurodegenerative dysfunction and is the most common cause of dementia in the elderly. AD generates progressive damage to brain tissue, causing the loss of synapses, lesions and neuronal death, in which the first committed part is the hippocampus region, responsible for memory development [3].…”