HMGB1 and CRP behaved differently in regards to their kinetic patterns, with HMGB1 appearing to better reflect the severity of tissue injury in dogs with GDV than CRP.

Reference intervals for traditionally- and Stewart's approach-determined acid-base parameters were established for venous and arterial blood in dogs.

ABSTRACT:The aim of this internet-based questionnaire was to determine risk factors for the development and survival of gastric dilatation and volvulus (GDV) in dogs in central Europe. The questionnaire focused on general information, feeding and elimination behaviour, family history, personality and routine habits, was freely distributed on the internet. Respondents were recruited by e-mail, and announcement of the survey on websites focused on dogs or breeder clubs and flyers in veterinary clinics and at dog shows. Responses from the owners of 785 dogs were analysed. Data underwent descriptive statistical and logistic regression analysis. Factors associated with an increased risk of GDV are intact male, specific breed, pet food and first-degree relative with gastric-dilatation and volvulus. In contrast, low risk was observed in spayed females, dogs eating meals with large particles, dogs with frequent defecation or in dogs kept at home. Non-survivors had a significantly longer time between food consumption and the development of clinical signs than survivors. We conclude that the risk of GDV development is associated with several factors. Some of these can be influenced by the owner or veterinarian.

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Gastric dilatation and volvulus syndrome is associated with changes in haemostatic profiles. The aims of this study were to compare selected haemostatic and fibrinolytic parameters between healthy dogs and dogs with gastric dilatation and volvulus syndrome, estimate the incidence of disseminated intravascular coagulation (DIC), and determine the most sensitive test for detection of DIC in these patients. Blood was collected from 22 dogs with gastric dilatation and volvulus syndrome, and nine healthy control dogs. Platelet counts, prothrombin time, activated partial thromboplastin time, fibrinogen concentrations and fibrin/fibrinogen degradation products were measured in all control dogs and patients with gastric dilatation and volvulus syndrome, before and after surgery. Significant differences between control dogs and patients were seen in activated partial thromboplastin time and fibrin/fibrinogen degradation products before surgery and all measured parameters after surgery. The incidence of DIC was 59%. The most sensitive tests for detection of DIC before surgery were those for activated partial thromboplastin time and fibrin/fibrinogen degradation products.Keywords: bleeding disorders; canine; coagulopathy; fibrin degradation products; haemostasis List of abbreviations aPTT = activated partial tromboplastin time, AT =antithrombin, DIC = disseminated intravascular coagulation, FBG = fibrinogen, FDP = fibrin degradation products, GDV = gastric dilatation and volvulus syndrome, PT = prothrombin time, SIRS = systemic inflammatory response syndrome