Acid-Base, Electrolyte and Lactate Abnormalities as Well as Gastric Necrosis and Survival in Dogs With Gastric Dilation-Volvulus Syndrome. A Retrospective Study in 75 Dogs

Raušerová-Lexmaulová, Leona; Vanova-Uhrikova, Ivana; Řeháková, Kristína

doi:10.1016/j.tcam.2020.100403

Cited by 6 publications

(10 citation statements)

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“…However, a reliable prognostic factor that would facilitate decision making before surgical therapy in a specific patient with GDV is yet to be found. The factor that is of highest benefit so far is the preoperative plasma lactate concentration, although not even lactate has a 100% predictive value (Beer et al 2013;Mooney et al 2014;Verschoof et al 2015;Rauserova-Lexmaulova et al 2020). Protein C activity evaluated in our study did not show to be a prognostic factor in these patients in terms of either mortality or severity of the disease (duration of clinical signs, degree of gastric torsion, gastric necrosis, splenectomy, DIC).…”

Section: Discussionmentioning

confidence: 48%

“…Previously, the duration of clinical signs was found to be associated with mortality in patients with GDV (Zatloukal et al 2005;Beck et al 2006;Rauserova-Lexmaulova et al 2020). Longer duration time negatively affects the stomach wall (Lantz et al 1984).…”

Section: Discussionmentioning

confidence: 99%

“…Different prognostic factors such as CRP, HMGB1, lactate, acid-base parameters, haemostatic indicators, lipase activity, canine pancreatic lipase immunoreactivity or myoglobin have been evaluated in dogs with GDV (Adamik et al 2009;Beer et al 2013;Mooney et al 2014;Uhrikova et al 2015;Verschoof et al 2015;Spinella et al 2018;Rauserova-Lexmaulova et al 2020). However, a reliable prognostic factor that would facilitate decision making before surgical therapy in a specific patient with GDV is yet to be found.…”

Section: Discussionmentioning

confidence: 99%

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Protein C activity in dogs with gastric dilatation and volvulus

et al. 2022

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Protein C activity, a novel prognostic marker, was evaluated in patients with gastric dilatation and volvulus in relation to mortality and severity of the disease. Data on the mortality, duration of clinical signs, degree of gastric torsion, gastric necrosis, splenectomy and occurrence of disseminated intravascular coagulopathy were recorded. Blood samples were obtained at selected time periods: T0 = no longer than 30 min before surgery; T1 = first day after surgery; T2 = second day after surgery. In addition to protein C activity assessment, haematological and haemostaseological analysis was also performed. The mean protein C activity was the lowest at T1 and the highest at T2. No significant relationship between protein C activity and mortality, duration of clinical signs, degree of gastric torsion, gastric necrosis, splenectomy and disseminated intravascular coagulopathy was found in patients with gastric dilatation and volvulus. All patients that died during hospitalisation after surgery were patients with decreased protein C activity at T1. Although protein C activity was not found to be a reliable preoperative prognostic marker in patients with gastric dilatation and volvulus, the study results show it might be a promising marker in postoperative monitoring of these patients.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protein C activity in dogs with gastric dilatation and volvulus

et al. 2022

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“…The 15-day mortality rate in this study was 20.7%. There is no comparable veterinary study with which to compare data, however, mortality rates reported in veterinary medicine for the most common surgical procedures encountered here, like gastrointestinal, hemoperitoneum or GDV syndrome surgeries, range from 0.8 to 28% [21][22][23][24][25][26], 12 to 36% [27,28] and 12 to 26 % [29][30][31][32][33][34][35][36], respectively.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Outcome in Dogs Undergoing Emergency Abdominal Surgery: A Retrospective Study on 82 Cases (2018-2020)

Fages¹,

Soler²,

Fernandez‐Salesa³

et al. 2021

Preprint

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Emergency abdominal surgery carries high morbidity and mortality rates in human medicine; however, there is less evidence characterizing the outcome of these surgeries as a single group in dogs. The aim of the study was to characterize the clinical course, associated complications and outcome of dogs undergoing emergency abdominal surgery. A retrospective study was conducted. Dogs undergoing emergency laparotomy were included in the study. Logistic regression analysis was performed to identify variables correlated with death and complications. Eighty-two dogs were included in the study. The most common reason for surgery was gastrointestinal foreign body. Overall 15-day mortality rate was 20.7% (17/82). Median (range) length of hospitalization was 3 (0.5 - 15) days. Of the 82 patients, 24 (29.3%) developed major complications and 66 (80.5%) minor complications. Perioperative factors significantly associated with death included tachycardia (P &lt; 0.001), hypothermia (P &lt; 0.001), lactate acidosis (P &lt; 0.001), shock index &gt; 1 (P &lt; 0.001), leukopenia (P &lt; 0.001), thrombocytopenia (P &lt; 0.001) at admission; intraoperative hypotension (P &lt; 0.001) and perioperative use of blood products (P &lt; 0.001). The results of this study suggest that mortality and morbidity rates after emergency abdominal surgery in dogs are high.

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“…The 15-day mortality rate in this study was 20.7%. There is no comparable veterinary study with which to compare data; however, mortality rates reported in veterinary medicine for the most common surgical procedures encountered here, such as gastrointestinal, hemoperitoneum or GDV syndrome surgeries, range from 0.8% to 28% [18][19][20][21][22][23], 12% to 36% [24,25] and 12% to 26% [26][27][28][29][30][31][32][33], respectively.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Outcome in Dogs Undergoing Emergency Abdominal Surgery: A Retrospective Study on 82 Cases (2018–2020)

Fages

Soler

Fernandez‐Salesa

et al. 2021

Veterinary Sciences

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Emergency abdominal surgery carries high morbidity and mortality rates in human medicine; however, there is less evidence characterising the outcome of these surgeries as a single group in dogs. The aim of the study was to characterise the clinical course, associated complications and outcome of dogs undergoing emergency abdominal surgery. A retrospective study was conducted. Dogs undergoing emergency laparotomy were included in the study. Logistic regression analysis was performed to identify variables correlated with death and complications. Eighty-two dogs were included in the study. The most common reason for surgery was a gastrointestinal foreign body. Overall, the 15-day mortality rate was 20.7% (17/82). The median (range) length of hospitalisation was 3 (0.5–15) days. Of the 82 patients, 24 (29.3%) developed major complications and 66 (80.5%) developed minor complications. Perioperative factors significantly associated with death included tachycardia (p < 0.001), hypothermia (p < 0.001), lactate acidosis (p < 0.001), shock index > 1 (p < 0.001), leukopenia (p < 0.001) and thrombocytopenia (p < 0.001) at admission, as well as intraoperative hypotension (p < 0.001) and perioperative use of blood products (p < 0.001). The results of this study suggest that mortality and morbidity rates after emergency abdominal surgery in dogs are high.

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Acid-Base, Electrolyte and Lactate Abnormalities as Well as Gastric Necrosis and Survival in Dogs With Gastric Dilation-Volvulus Syndrome. A Retrospective Study in 75 Dogs

Cited by 6 publications

References 50 publications

Protein C activity in dogs with gastric dilatation and volvulus

Protein C activity in dogs with gastric dilatation and volvulus

Perioperative Outcome in Dogs Undergoing Emergency Abdominal Surgery: A Retrospective Study on 82 Cases (2018-2020)

Perioperative Outcome in Dogs Undergoing Emergency Abdominal Surgery: A Retrospective Study on 82 Cases (2018–2020)

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