Symptoms associated with PADAM often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes. It is likely that these symptoms have a more complex background than only PADAM.

Symptoms of Late onset Hypogonadism (LOH) and concentrations of Testosterone (T) andBioavailable Testosterone (BT) were studied in relation to the data from the same men five years earlier. Methods:In 2008, 282 men, 60-82 years answered a questionnaire regarding demographic data, medical history, different symptoms of LOH and the 10 questions from the "ADAM-questionnaire".Blood samples were analysed for concentrations of T and calculations were made for BT.Results: 87.2% of the questionnaires were returned and analysed, and 75.2% of the responders gave blood samples. The oldest third of the men were most affected by LOH symptoms (p<0.05). Both T and BT-concentrations decreased during the five years (p<0.05) but only the symptom "less strong erections" changed significantly (p<0.05). Men reporting one of four specific symptoms from the "ADAM-questionnaire" for the first time in 2008 had a higher loss of T and BT than men who had unchanged or fewer symptoms than reported in 2003. Conclusions:The magnitude of the decrease in concentrations is a better predictor of LOH than are the actual concentrations of T and or BT. A combination of symptoms predicts LOH better than any single symptom.

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